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盐酸酪胺

盐酸酪胺用途

Tyramine hydrochloride 是一种有助于调节血压的氨基酸。Tyramine 天然存在于体内,并存在于某些食物中。

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盐酸酪胺名称

[ CAS 号 ]:
60-19-5

[ 中文名 ]:
酪胺盐酸盐

[ 英文名 ]:
Tyramine

[中文别名 ]:

[英文别名 ]:

p-b-Aminoethylphenol
P-hydroxy-b-phenylethylamine
Z2R DQ
MFCD00012682
4-Hydroxy phenylethylamine
EINECS 206-446-4
4-hydroxy-Benzeneethanamine
Phenol, p- (2-aminoethyl)-
4-Hydroxy-β-phenylethylamine
4- (2-aminoethyl)-Phenol

盐酸酪胺生物活性

[ 描述 ]:

Tyramine hydrochloride 是一种有助于调节血压的氨基酸。Tyramine 天然存在于体内,并存在于某些食物中。

[ 相关类别 ]:

研究领域 >> 心血管疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

酪胺通常被一种叫做MAO(单胺氧化酶)的酶分解[1]。

[参考文献]

[1]. C Brown , et al. The Monoamine Oxidase Inhibitor-Tyramine Interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32.

盐酸酪胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
325.2±0.0 °C at 760 mmHg

[ 熔点 ]:
253-255 °C(lit.)

[ 分子式 ]:
C₈H₁₂ClNO

[ 分子量 ]:
137.179

[ 闪点 ]:
119.2±20.4 °C

[ 精确质量 ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.72

[ 外观性状 ]:
略米色/几乎无气味的

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
水溶性：可溶

盐酸酪胺MSDS

盐酸酪胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ6050000

CHEMICAL NAME :: Phenol, p-(2-aminoethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 60-19-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H11-N-O.Cl-H

MOLECULAR WEIGHT :: 173.66

WISWESSER LINE NOTATION :: Z2R DQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1044 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 2530 umol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988

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盐酸酪胺安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S36-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL4375000

[ 海关编码 ]:
29222900

盐酸酪胺合成路线

盐酸酪胺上下游产品

盐酸酪胺上游产品

盐酸酪胺下游产品

盐酸酪胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸酪胺文献

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New procedure of selected biogenic amines determination in wine samples by HPLC.

Anal. Chim. Acta 834 , 58-66, (2014)

A new procedure for determination of biogenic amines (BA): histamine, phenethylamine, tyramine and tryptamine, based on the derivatization reaction with 2-chloro-1,3-dinitro-5-(trifluoromethyl)-benzen...

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.

Viral Immunol. 27(10) , 484-96, (2014)

Immunopathologic examination of the lungs of mice with experimental influenza virus infection reveals three prominent findings. (i) There is rapidly developing perivascular (arterial) and peribronchia...

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