牛磺鹅去氧胆酸钠

牛磺鹅去氧胆酸钠用途

Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis),并具有明显的抗炎和免疫调节作用。

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牛磺鹅去氧胆酸钠名称

[ CAS 号 ]:
6009-98-9

[ 中文名 ]:
牛磺鹅去氧胆酸钠

[ 英文名 ]:
Taurochenodeoxycholic acid sodium salt

[中文别名 ]:

[英文别名 ]:

taurochenodeoxycholic acid sodium salt
MFCD00036745

牛磺鹅去氧胆酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

牛磺胆酸能显著提高NR8383细胞的凋亡率,且呈浓度依赖性。同时,牛磺胆酸显著提高PKC的mRNA水平和活性,提高JNK、caspase-3和caspase-8mrna的表达水平和活性[1]。

[体内研究]

牛磺胆酸(0.05,0.1g/kg)降低模型小鼠肺系数,减轻肺组织病理损伤；降低肺纤维化小鼠肺组织中TNF-α和TIMP-2的表达水平,对MMP2无明显影响[2]。牛磺胆酸能显著使临床炎症参数正常化,防止消炎痛引起的继发性胆汁酸含量和疏水指数升高,并有减轻肠道炎症的趋势[3]。牛磺胆酸能显著抑制AA大鼠足肿胀和多关节炎指数,增加胸腺和脾脏指数,改善AA大鼠的放射学改变。所有TCDCA治疗大鼠血清和滑膜组织中TNF-α、IL-1β和IL-6的过度分泌和mRNA表达均受到显著抑制[4]。

[参考文献]

[1]. Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15.

[2]. Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5.

[3]. Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57.

[4]. Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8.

牛磺鹅去氧胆酸钠物理化学性质

[ 密度 ]:
1.164 g/mL at 25 °C(lit.)

[ 沸点 ]:
215 °C(lit.)

[ 分子式 ]:
C₂₆H₄₄NNaO₆S

[ 分子量 ]:
521.685

[ 闪点 ]:
195 °F

[ 精确质量 ]:
521.278687

[ PSA ]:
135.14000

[ LogP ]:
4.52640

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
n20/D 1.558(lit.)

[ 储存条件 ]:
室温，干燥，密封

牛磺鹅去氧胆酸钠MSDS

详细MSDS(安全技术说明书)

牛磺鹅去氧胆酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

牛磺鹅去氧胆酸钠合成路线

详细合成路线

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牛磺鹅去氧胆酸钠文献

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Bile acids repress hypoxia-inducible factor 1 signaling and modulate the airway immune response.

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Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric cont...

Metabolomics reveals novel biomarkers of illegal 5-nitromimidazole treatment in pigs. Further evidence of drug toxicity uncovered.

Food Chem. 199 , 876-84, (2016)

The aim of the study was to investigate the potential of a metabolomics platform to distinguish between pigs treated with ronidazole, dimetridazole and metronidazole and non-medicated animals (control...

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