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氯舒隆

氯舒隆用途

Clorsulon可作用于牛和羊的肝片吸虫感染。

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氯舒隆名称

[ CAS 号 ]:
60200-06-8

[ 中文名 ]:
克洛索隆

[ 英文名 ]:
Clorsulon

[中文别名 ]:

[英文别名 ]:

Clorsulon [Spanish]
UNII-EG1ZDO6LRD
EINECS 262-100-2
Clorsulonum [Latin]
4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide
Ivomec-F
MFCD00072006
Clorsulone [French]
Clorsulon
Curatrem

氯舒隆生物活性

[ 描述 ]:

Clorsulon可作用于牛和羊的肝片吸虫感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7.

[2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41.

[相关活性小分子]

氯舒隆物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
651.7±65.0 °C at 760 mmHg

[ 熔点 ]:
194-203°C

[ 分子式 ]:
C₈H₈Cl₃N₃O₄S₂

[ 分子量 ]:
380.656

[ 闪点 ]:
348.0±34.3 °C

[ 精确质量 ]:
378.902191

[ PSA ]:
163.10000

[ LogP ]:
1.04

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.665

[ 储存条件 ]:
0-6°C

氯舒隆MSDS

详细MSDS(安全技术说明书)

氯舒隆毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9090000

CHEMICAL NAME :: 1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-

CAS REGISTRY NUMBER :: 60200-06-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H8-Cl3-N3-O4-S2

MOLECULAR WEIGHT :: 380.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 761 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

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氯舒隆安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CZ9090000

[ 海关编码 ]:
2935009090

氯舒隆上下游产品

氯舒隆上游产品

氯舒隆下游产品

氯舒隆海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

氯舒隆文献

Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon.

Exp. Parasitol. 136 , 59-62, (2014)

In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anth...

Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance.

Parasitol. Res. 113(7) , 2733-41, (2014)

In the current study, Fasciola hepatica strains of sheep with different degrees of resistance to anthelmintics were analyzed by sequencing the cytochrome C oxidase (COX1) and the NADH dehydrogenase (N...

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

Vet. Parasitol. 162(3-4) , 278-84, (2009)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit...

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氯舒隆