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L-高半胱氨酸

L-高半胱氨酸用途

L-Homocysteine 是一种高半胱氨酸代谢物,是有 L 构型的高半胱氨酸。高同型半胱氨酸血症中,L-Homocysteine 诱导的组织蛋白酶 V 上调介导了血管内皮炎症。

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L-高半胱氨酸名称

[ CAS 号 ]:
6027-13-0

[ 中文名 ]:
L-高半胱氨酸

[ 英文名 ]:
DL-Homocysteine

[英文别名 ]:

(2S)-2-amino-4-sulfanylbutanoic acid
Homocysteine, L-
L-2-Amino-4-Mercapto-butyric acid
(S)-2-amino-4-mercapto-Butanoic acid
DL-2-amino-4-mercapto-Butyric acid
HOMO-CYS
H-Hcys-OH
Butyric acid, 2-amino-4-mercapto-
DL-2-Amino-4-mercaptobutyric acid
Butyric acid, 2-amino-4-mercapto-, DL-

L-高半胱氨酸生物活性

[ 描述 ]:

L-Homocysteine 是一种高半胱氨酸代谢物,是有 L 构型的高半胱氨酸。高同型半胱氨酸血症中,L-Homocysteine 诱导的组织蛋白酶 V 上调介导了血管内皮炎症。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Finkelstein JD, et al. Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9.

[2]. Leng YP, et al. l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Br J Pharmacol. 2018 Apr;175(8):1157-1172.

L-高半胱氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
299.7±35.0 °C at 760 mmHg

[ 熔点 ]:
231 °C

[ 分子式 ]:
C₄H₉NO₂S

[ 分子量 ]:
135.185

[ 闪点 ]:
135.0±25.9 °C

[ 精确质量 ]:
135.035400

[ PSA ]:
102.12000

[ LogP ]:
0.22

[ 外观性状 ]:
无色或几乎无色固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
?20°C

L-高半胱氨酸MSDS

L-高半胱氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

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L-高半胱氨酸文献

Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.

J. Nutr. 144(5) , 714-21, (2014)

Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may als...

Abstracts of the 9th International Conference On Homocysteine and One-Carbon Metabolism - HCY2013. Dublin, Ireland. September 8-12, 2013.

J. Inherit. Metab. Dis. 36 Suppl 1 , S1-54, (2013)

Derivation and validation of homocysteine score in u.s. Men and women.

J. Nutr. 145(1) , 96-104, (2015)

One-carbon metabolism, which is crucial in DNA synthesis and genomic stability, is an interrelated network of biochemical reactions involved in several dietary and lifestyle factors. The development o...

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