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S-腺苷-L-高半胱氨酸

S-腺苷-L-高半胱氨酸用途

SAH是氨基酸衍生物和几种代谢途径中的调节剂。它是半胱氨酸和腺苷合成的中间体。

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S-腺苷-L-高半胱氨酸名称

[ CAS 号 ]:
979-92-0

[ 中文名 ]:
S-腺苷-L-高半胱氨酸

[ 英文名 ]:
SAH

[中文别名 ]:

[英文别名 ]:

S-(5'-Adenosyl)-L-homocysteine
(2S)-adenosylhomocysteine
Adenosylhomocysteine
Adenosyl-L-homocysteine
AdenosylhoMocysteine-13C5
HOMOCYSTEINE,S-ADENOSYL
L-S-AdenosylhoMocysteine
s-adenosylhomocysteine
S-ADENOSYL-L-HOMOCYSTEINE
L-adenosyl-L-homocysteine

S-腺苷-L-高半胱氨酸生物活性

[ 描述 ]:

SAH是氨基酸衍生物和几种代谢途径中的调节剂。它是半胱氨酸和腺苷合成的中间体。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234(3):603-8.

[相关活性小分子]

S-腺苷-L-高半胱氨酸物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
787.5±70.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₂₀N₆O₅S

[ 分子量 ]:
384.411

[ 闪点 ]:
430.0±35.7 °C

[ 精确质量 ]:
384.121582

[ PSA ]:
207.93000

[ LogP ]:
0.15

[ 外观性状 ]:
crystalline

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.839

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
1 M HCl: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow

S-腺苷-L-高半胱氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

S-腺苷-L-高半胱氨酸合成路线

详细合成路线

S-腺苷-L-高半胱氨酸上下游产品

S-腺苷-L-高半胱氨酸上游产品

S-腺苷-L-高半胱氨酸下游产品

S-腺苷-L-高半胱氨酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

S-腺苷-L-高半胱氨酸文献

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.

Mol. Ther. 23(1) , 32-42, (2015)

Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of l...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily.

Biochemistry 48(42) , 10162-74, (2009)

RimO, encoded by the yliG gene in Escherichia coli, has been recently identified in vivo as the enzyme responsible for the attachment of a methylthio group on the beta-carbon of Asp88 of the small rib...

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