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Taurolithocholic Acid sodium salt

Taurolithocholic Acid sodium salt用途

牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。

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Taurolithocholic Acid sodium salt名称

[ CAS 号 ]:
6042-32-6

[ 中文名 ]:
牛磺石胆酸钠盐

[ 英文名 ]:
TAUROLITHOCHOLIC ACID SODIUM SALT

[中文别名 ]:

[英文别名 ]:

sodium taurolithocholic acid
sodium taurolithocholate
SODIUM TAUROLITHOCHOLATE SODIUM SALT
taurolithocholic acid sodium
TAUROLITHIOCHOLIC ACID SODIUM

Taurolithocholic Acid sodium salt生物活性

[ 描述 ]:

牛磺胆酸钠盐是一种有效的胆汁抑制剂,是一种有效的钙离子激动剂[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 代谢疾病

[体外研究]

低浓度(5µM)的牛磺胆酸(TLCA)倾向于选择性地将PKC e-亚型的膜相关部分增加44.1%±40.2%[1]。TLCA(10µM)选择性诱导PKCε-亚型移位到肝细胞膜,这是激活可移动PKC亚型的关键步骤[1]。

[体内研究]

牛磺胆酸(TLCA)通过PI3K依赖机制在灌流大鼠肝脏和大鼠肝细胞偶联物中发挥胆汁抑制作用[2]。

[参考文献]

[1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82.

[2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8.

Taurolithocholic Acid sodium salt物理化学性质

[ 分子式 ]:
C₂₆H₄₄NNaO₅S

[ 分子量 ]:
505.68600

[ 精确质量 ]:
505.28400

[ PSA ]:
114.91000

[ LogP ]:
5.55560

[ 储存条件 ]:
-20°C，密闭，干燥

Taurolithocholic Acid sodium saltMSDS

详细MSDS(安全技术说明书)

Taurolithocholic Acid sodium salt安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Taurolithocholic Acid sodium salt文献

Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.

Arterioscler. Thromb. Vasc. Biol. 33(7) , 1663-9, (2013)

TGR5 is a G-protein-coupled receptor for bile acids. So far, little is known about the function of TGR5 in vascular endothelial cells.In bovine aortic endothelial cells, treatment with a bile acid hav...

Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.

PLoS ONE 7(12) , e52647, (2012)

Angiotensin II (AT-II) is a pro-fibrotic compound that acts via membrane-bound receptors (AT-1R/AT-2R) and thereby activates hepatic stellate cells (HSCs). AT-II receptor blockers (ARBs) are thus impo...

Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.

J. Biol. Chem. 288(1) , 570-80, (2013)

Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic a...

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