甲氧胺 盐酸盐
甲氧胺 盐酸盐用途
甲氧胺 盐酸盐名称
[ CAS 号 ]:
61-16-5
[ 中文名 ]:
盐酸甲氧明
[ 英文名 ]:
methoxamine hydrochloride
[中文别名 ]:
[英文别名 ]:
- Methoxamine HCl
- Methoxamini hydrochloridum
- METHOXAMINE HYDROCHLORIDE
- EINECS 200-499-7
- Pressomin hydrochloride
- Idasal
- Vasoxyl hydrochloride
- MFCD00058607
- Vasylox hydrochloride
甲氧胺 盐酸盐生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Noradrenergic α1[1].
[体外研究]
[参考文献]
甲氧胺 盐酸盐物理化学性质
[ 沸点 ]:
368.4ºC at 760 mmHg
[ 熔点 ]:
212-216ºC
[ 分子式 ]:
C11H18ClNO3
[ 分子量 ]:
247.71900
[ 闪点 ]:
176.6ºC
[ 精确质量 ]:
247.09800
[ PSA ]:
64.71000
[ LogP ]:
2.58670
[ 外观性状 ]:
固体
[ 折射率 ]:
1.5204
[ 储存条件 ]:
2-8°C
甲氧胺 盐酸盐MSDS
甲氧胺 盐酸盐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DN4025000
- CHEMICAL NAME :
- Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride
- CAS REGISTRY NUMBER :
- 61-16-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C11-H17-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 247.75
- WISWESSER LINE NOTATION :
- ZY1&YQR BO1 EO1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,160,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,283,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5030 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,289,1970 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intratesticular
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- male 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 58,19,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5310 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 988 (estimated) No. of Female Employees: 625 (estimated)
甲氧胺 盐酸盐安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
DN4025000
甲氧胺 盐酸盐文献
Vascul. Pharmacol. 63(1) , 4-12, (2014)
The role of calcitonin gene-related peptide (CGRP) in the modulation of vascular tone has been widely documented. Indeed, electrical stimulation of the perivascular sensory outflow in pithed rats indu...
Lipophilicity of amine neurotransmitter precursors, metabolites and related drugs estimated on various TLC plates.J. Chromatogr. Sci. 52(9) , 1095-103, (2014)
The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-...
Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.J. Med. Assoc. Thai. 95 Suppl 12 , S63-8, (2012)
To investigate the effects of gamma-mangostin on vascular tone and its mechanisms in the isolated rat aorta.Aortic rings from male Wistar rats were precontracted with methoxamine. Changes in tension w...
相关化工产品/化学物质：
相关药品：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：盐酸甲氧明
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Methoxamine Hydrochloride
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥1499.9/1g
￥559.9/250mg
￥937.9/500mg
￥6399.9/5g
联系人：阿拉丁
产品详情：甲氧胺 盐酸盐
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相关化合物
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