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噻嗪磺胺

噻嗪磺胺用途

Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。

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噻嗪磺胺名称

[ CAS 号 ]:
61-56-3

[ 中文名 ]:
噻嗪磺胺

[ 英文名 ]:
Sulthiame

[英文别名 ]:

Sulthiamine
Sultiamum
Trolone
SULTHIAME
sultiame
Conadil
Riker 594
Ospolot
Contravul
Sulphenyltame

噻嗪磺胺生物活性

[ 描述 ]:

Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶

研究领域 >> 神经疾病

[体外研究]

Sultiame(Sulthiame)是一种磺胺,它可以通过作为碳酸酐酶抑制剂在中枢神经元中产生适度的细胞内酸中毒而发挥抗癫痫活性,从而降低动作电位和癫痫样突发的频率[1]。

[参考文献]

[1]. Milburn-McNulty P, et al. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472.

[相关活性小分子]

噻嗪磺胺物理化学性质

[ 密度 ]:
1.472g/cm3

[ 沸点 ]:
520.2ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₄N₂O₄S₂

[ 分子量 ]:
290.35900

[ 闪点 ]:
268.4ºC

[ 精确质量 ]:
290.03900

[ PSA ]:
114.30000

[ LogP ]:
3.19090

[ 外观性状 ]:
固体

[ 折射率 ]:
1.609

[ 储存条件 ]:
2-8°C，干燥

噻嗪磺胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB3150000

CHEMICAL NAME :: Benzenesulfonamide, p-(tetrahydro-2H-1,2-thiazin-2-yl)-, dioxide

CAS REGISTRY NUMBER :: 61-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H14-N2-O4-S2

MOLECULAR WEIGHT :: 290.38

WISWESSER LINE NOTATION :: T6NSWTJ AR DSZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 25,229,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,383,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4852 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1668 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972

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噻嗪磺胺安全信息

[ 海关编码 ]:
2935009090

噻嗪磺胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%