< 生产厂家 价格 >

双氯非那胺

双氯非那胺用途

Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。
点击显示

双氯非那胺名称

[ CAS 号 ]:
120-97-8

[ 中文名 ]:
双氯非那胺

[ 英文名 ]:
diclofenamide

[中文别名 ]:

[英文别名 ]:

双氯非那胺生物活性

[ 描述 ]:

Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
研究领域 >> 神经疾病

[参考文献]

[1]. Kanski, J.J., Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. Br J Ophthalmol, 1968. 52(8): p. 642-3.

[2]. Rucquoy, M. and L. Sorel, Diclofenamide in the treatment of therapy-resistant epilepsy. Acta Neurol Belg, 1978. 78(3): p. 174-82.


[相关活性小分子]

布林佐胺 | 醋甲唑胺 | 盐酸多佐胺 | 依索唑胺 | U形104 | 噻嗪磺胺 | 噻克索酮 | 2-氨基苯磺酰胺 | 苄噻嗪

双氯非那胺物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
590.5±60.0 °C at 760 mmHg

[ 熔点 ]:
239-241ºC

[ 分子式 ]:
C6H6Cl2N2O4S2

[ 分子量 ]:
305.159

[ 闪点 ]:
310.9±32.9 °C

[ 精确质量 ]:
303.914612

[ PSA ]:
137.08000

[ LogP ]:
0.93

[ 外观性状 ]:
白色或几乎白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
水溶性：不溶

双氯非那胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ9200000
CHEMICAL NAME :
m-Benzenedisulfonamide, 4,5-dichloro-
CAS REGISTRY NUMBER :
120-97-8
BEILSTEIN REFERENCE NO. :
2703329
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C6-H6-Cl2-N2-O4-S2
MOLECULAR WEIGHT :
305.16
WISWESSER LINE NOTATION :
ZSWR BG CG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
304 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 19,1423,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
643 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4642 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,6,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
500 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 11,31,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
96 mg/kg
SEX/DURATION :
female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
DEBIAO Developmental Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,395,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
144 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,239,1971
点击显示

双氯非那胺安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R63

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CZ9200000

[ 海关编码 ]:
2935009090

双氯非那胺合成路线

详细合成路线

双氯非那胺上下游产品

双氯非那胺上游产品

双氯非那胺下游产品

双氯非那胺制备

二、生产方法简述

由邻二氯苯经氯磺化、胺化而得
点击显示

双氯非那胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

相关药品：

推荐生产厂家/供应商：

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Dichlorphenamide (Diclofenamide)

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥2649.0/100mg ￥929.0/1g ￥1649.0/50mg ￥879.0/50mg

联系人：李先生

产品详情：Dichlorphenamide

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2368.9/1g ￥823.9/250mg ￥308.9/50mg ￥需询单/1g

联系人：阿拉丁李高志

产品详情：双氯非那胺

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥772.0/1mg ￥2606.8/100mg ￥需询单/1ml ￥1626.8/50mg

联系人：夏言

产品详情：[Perfemiker]Dichlorphenamide,99%

公司名：上海陌孚医药科技有限公司

区域：上海市嘉定区

价格：
￥2346.12/100mg ￥需询单/1mg ￥784.98/10mg ￥1464.12/50mg

联系人：朱经理

产品详情：Dichlorphenamide

查看所有供应商请点击：

双氯非那胺供应商

相关化合物

【双氯非那胺】化源网提供双氯非那胺CAS号120-97-8，双氯非那胺MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询双氯非那胺上化源网，专业又轻松。>>电脑版：双氯非那胺

标题：双氯非那胺_用途_密度_熔点_双氯非那胺CAS号【120-97-8】_化源网 地址：https://m.chemsrc.com/mip/cas/120-97-8_834134.html