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硫酸天仙子胺水合物

硫酸天仙子胺水合物用途

L-Hyoscyamine sulfate (Daturine sulfate) 是一种莨菪烷生物碱,是茄科某些植物的次生代谢物。体外实验表明它是一种 mAChR 受体的拮抗剂。

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硫酸天仙子胺水合物名称

[ CAS 号 ]:
620-61-1

[ 中文名 ]:
莨菪碱硫酸盐

[ 英文名 ]:
Hyoscyamine sulfate hydrate

[中文别名 ]:

[英文别名 ]:

Atropina Solfato
UNII:03J5ZE7KA5
L-TROPINE TROPATE SULFATE
atropine sulphate
L-Hyoscyamine Hemisulfate
atropin sulfate
Atropine Sulfate Monohydrate
MFCD00078244
levsinsulfate
EINECS 210-644-6

硫酸天仙子胺水合物生物活性

[ 描述 ]:

L-Hyoscyamine sulfate (Daturine sulfate) 是一种莨菪烷生物碱,是茄科某些植物的次生代谢物。体外实验表明它是一种 mAChR 受体的拮抗剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Jones JB, et al. Sublingual hyoscyamine sulfate in combination with ketorolac tromethamine for ureteral colic: a randomized, double-blind, controlled trial. Ann Emerg Med. 2001 Feb;37(2):141-6.

硫酸天仙子胺水合物物理化学性质

[ 熔点 ]:
205-206ºC

[ 分子式 ]:
C₁₇H₂₄NO₅S_0.5

[ 分子量 ]:
676.817

[ 精确质量 ]:
676.302979

[ PSA ]:
191.75000

[ LogP ]:
4.10130

[ 折射率 ]:
-28 ° (C=5, H2O)

[ 储存条件 ]:
2-8°C，干燥，密封

硫酸天仙子胺水合物MSDS

详细MSDS(安全技术说明书)

硫酸天仙子胺水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM6107000

CAS REGISTRY NUMBER :: 620-61-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C34-H46-N2-O6.H2-O4-S

MOLECULAR WEIGHT :: 676.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 400 uL/kg/1D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 800 uL/kg/1D-I

TOXIC EFFECTS :: Behavioral - irritability Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 400 uL/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 55,849,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80431 No. of Facilities: 967 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80431 No. of Facilities: 445 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 14970 (estimated) No. of Female Employees: 12609 (estimated)

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硫酸天仙子胺水合物安全信息

[ 风险声明 (欧洲) ]:
R26/28

[ 安全声明 (欧洲) ]:
S1;S45;S24/25

[ RTECS号 ]:
YM6107000