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3'-羟基乙酰苯胺

3'-羟基乙酰苯胺用途

Metacetamol is an isomer of paracetamol and it similarly exhibits polymorphism.

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3'-羟基乙酰苯胺名称

[ CAS 号 ]:
621-42-1

[ 中文名 ]:
N-(3-羟基苯基)乙酰胺

[ 英文名 ]:
1-(3-Hydroxyphenyl)urea

[中文别名 ]:

[英文别名 ]:

Urea, N-(3-hydroxyphenyl)-
3-ACETAMIDOPHENOL
1-(3-Hydroxyphenyl)urea
m-Acetamidophenol
3-hydroxyacetoanilide
N-Acetyl-m-aminophenol
m-hydroxyacetanilide
MFCD00002263
3'-Hydroxyacetanilide
m-acetylaminophenol

3'-羟基乙酰苯胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
313.1±25.0 °C at 760 mmHg

[ 熔点 ]:
145-148 °C(lit.)

[ 分子式 ]:
C₈H₉NO₂

[ 分子量 ]:
152.151

[ 闪点 ]:
143.2±23.2 °C

[ 精确质量 ]:
152.058578

[ PSA ]:
49.33000

[ LogP ]:
0.36

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.690

[ 储存条件 ]:
2-8°C

3'-羟基乙酰苯胺MSDS

3'-羟基乙酰苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4100000

CHEMICAL NAME :: Acetanilide, 3'-hydroxy-

CAS REGISTRY NUMBER :: 621-42-1

BEILSTEIN REFERENCE NO. :: 0907998

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: QR CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1025 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 28,447,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6632 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) No. of Female Employees: 151 (estimated)

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3'-羟基乙酰苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn;Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ RTECS号 ]:
AE4100000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29242995

3'-羟基乙酰苯胺合成路线

3'-羟基乙酰苯胺上下游产品

3'-羟基乙酰苯胺上游产品

3'-羟基乙酰苯胺下游产品

3'-羟基乙酰苯胺制备

由间氨基酚经乙酰化、烷基化、水解，中和而得。

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3'-羟基乙酰苯胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3'-羟基乙酰苯胺文献

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

更多文献

3'-羟基乙酰苯胺

3'-羟基乙酰苯胺用途

3'-羟基乙酰苯胺名称

3'-羟基乙酰苯胺物理化学性质

3'-羟基乙酰苯胺MSDS

详细MSDS(安全技术说明书)

3'-羟基乙酰苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

3'-羟基乙酰苯胺安全信息

3'-羟基乙酰苯胺合成路线

详细合成路线

3'-羟基乙酰苯胺上下游产品

3'-羟基乙酰苯胺上游产品

3'-羟基乙酰苯胺下游产品

3'-羟基乙酰苯胺制备

3'-羟基乙酰苯胺海关

3'-羟基乙酰苯胺文献

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