β-乳香酸

β-乳香酸用途

β-Boswellic acid 是从乳香 Boswellia serrate 的树胶脂中分离出来的。β-Boswellic acid 是 5-脂氧合酶 (5-LO) 产物形成的非还原型抑制剂,其直接与 5-LO 相互作用或阻断其易位。β-Boswellic acid 抑制人白血病 HL-60 细胞中 DNA,RNA和蛋白质的合成。

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β-乳香酸名称

[ CAS 号 ]:
631-69-6

[ 中文名 ]:
beta-乳香酸

[ 英文名 ]:
Beta-boswellic acid

[中文别名 ]:

[英文别名 ]:

b-Boswellic Acid
β-BOSWELLIC ACID
Urs-12-en-24-oic acid, 3-hydroxy-, (3α,9ξ)-
(3a,4b)-3-Hydroxyurs-12-en-23-oic Acid
(3α,9ξ)-3-Hydroxyurs-12-en-24-oic acid

β-乳香酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Safayhi H, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.

[2]. Shao Y, et al. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cellsin culture. Planta Med. 1998 May;64(4):328-31

β-乳香酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
556.0±50.0 °C at 760 mmHg

[ 熔点 ]:
130-135ºC

[ 分子式 ]:
C₃₀H₄₈O₃

[ 分子量 ]:
456.700

[ 闪点 ]:
304.1±26.6 °C

[ 精确质量 ]:
456.360352

[ PSA ]:
57.53000

[ LogP ]:
9.38

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
2-8°C

β-乳香酸安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2918199090

β-乳香酸合成路线

详细合成路线

β-乳香酸上下游产品

β-乳香酸上游产品

β-乳香酸下游产品

β-乳香酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

β-乳香酸文献

Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.

Bioorg. Med. Chem. Lett. 22 , 431-5, (2012)

Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines...

A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.

Eur. J. Med. Chem. 46 , 1356-66, (2011)

Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical c...

The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.

Adv. Ther. 28(10) , 894-906, (2011)

Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inf...

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