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消旋甲酪氨酸

消旋甲酪氨酸用途

α-甲基-p-酪氨酸是酪氨酸羟化酶的竞争性抑制剂,该酶将酪氨酸转化为左旋多巴(DOPA)。α-甲基-p-酪氨酸是儿茶酚胺合成的口服活性抑制剂,其抑制酪氨酸羟基化为多巴[1]。

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消旋甲酪氨酸名称

[ CAS 号 ]:
658-48-0

[ 中文名 ]:
消旋甲酪氨酸

[ 英文名 ]:
a-methyl-D-tyrosine

[中文别名 ]:

[英文别名 ]:

MFCD00004187
a-methyl-D-tyrosine
a-methyl-dl-p-tyrosine
EINECS 211-523-0
D-Tyrosine, α-methyl-
(-)-α-Methyl-D-tyrosine
D-tyrosine, a-methyl-
α-Methyl-D-tyrosine

消旋甲酪氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. R N Brogden, et al. alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs. 1981 Feb;21(2):81-9.

消旋甲酪氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
383.7±32.0 °C at 760 mmHg

[ 熔点 ]:
>300ºC(lit.)

[ 分子式 ]:
C₁₀H₁₃NO₃

[ 分子量 ]:
195.215

[ 闪点 ]:
185.9±25.1 °C

[ 精确质量 ]:
195.089539

[ PSA ]:
83.55000

[ LogP ]:
0.73

[ 外观性状 ]:
灰白色细粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
−20°C

消旋甲酪氨酸MSDS

消旋甲酪氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2890000

CHEMICAL NAME :: Tyrosine, alpha-methyl-

CAS REGISTRY NUMBER :: 658-48-0

BEILSTEIN REFERENCE NO. :: 2938704

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H13-N-O3

MOLECULAR WEIGHT :: 195.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,435,1970

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消旋甲酪氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2890000

[ 海关编码 ]:
2922509090

消旋甲酪氨酸合成路线

消旋甲酪氨酸上下游产品

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消旋甲酪氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

消旋甲酪氨酸文献

Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.

Neuropharmacology 93 , 124-33, (2015)

Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxi...

Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.

Neuropharmacology 89 , 204-14, (2014)

FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in re...

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

Endocrinology 156 , 2470-81, (2015)

Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction be...

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