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丙二醇

丙二醇用途

(±)-1,2-Propanediol 是一种脂肪族醇,在许多药物制剂中经常被用作赋形剂以增加药物的溶解性和稳定性。
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丙二醇名称

[ CAS 号 ]:
57-55-6

[ 中文名 ]:
1,2-丙二醇

[ 英文名 ]:
Propylene Glycol

[中文别名 ]:

[英文别名 ]:

丙二醇生物活性

[ 描述 ]:

(±)-1,2-Propanediol 是一种脂肪族醇,在许多药物制剂中经常被用作赋形剂以增加药物的溶解性和稳定性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
生化试剂
研究领域 >> 其他

[参考文献]

[1]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

丙二醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
184.8±8.0 °C at 760 mmHg

[ 熔点 ]:
-60ºC

[ 分子式 ]:
C3H8O2

[ 分子量 ]:
76.094

[ 闪点 ]:
107.2±0.0 °C

[ 精确质量 ]:
76.052429

[ PSA ]:
40.46000

[ LogP ]:
-1.34

[ 外观性状 ]:
透明粘性液体

[ 蒸汽密度 ]:
2.62 (vs air)

[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C

[ 折射率 ]:
1.430

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
miscible

丙二醇MSDS

详细MSDS(安全技术说明书)

丙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TY2000000
CHEMICAL NAME :
1,2-Propanediol
CAS REGISTRY NUMBER :
57-55-6
BEILSTEIN REFERENCE NO. :
1340498
LAST UPDATED :
199712
DATA ITEMS CITED :
42
MOLECULAR FORMULA :
C3-H8-O2
MOLECULAR WEIGHT :
76.11
WISWESSER LINE NOTATION :
QY1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human - man
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
79 gm/kg/56W-I
TOXIC EFFECTS :
Brain and Coverings - changes in surface EEG Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
10 gm/kg/3D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6423 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9718 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17370 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6630 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
22 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
26 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
18500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
18350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
15500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
27 gm/kg
TOXIC EFFECTS :
Vascular - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>2080 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2180 mg/m3/6H/90D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
32 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 63525 No. of Facilities: 83144 (estimated) No. of Industries: 323 No. of Occupations: 224 No. of Employees: 1494465 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 63525 No. of Facilities: 92966 (estimated) No. of Industries: 347 No. of Occupations: 244 No. of Employees: 2238429 (estimated) No. of Female Employees: 936584 (estimated)
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丙二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TY2000000

[ 海关编码 ]:
2905320000

丙二醇合成路线

详细合成路线

丙二醇上下游产品

丙二醇上游产品

丙二醇下游产品

丙二醇制备

1. 环氧丙烷直接水合法　为加压非催化水解法。由环氧丙烷与水在150-160℃、0.78-0.98MPa压力下，直接水合制得，反应产物经蒸发、精馏，得成品。 2. 环氧丙烷间接水合法　由环氧丙烷与水用硫酸作催化剂间接水合制得。 3. 丙烯直接催化氧化法。 4. 采用1,2-二氯丙烷为原料 该法有两条工艺路线：一是二氯丙烷在弱碱水溶液中直接水解成丙二醇；二是二氯丙烷和羧酸盐反应先生成酯，酯再水解成丙二醇。（一）直接水解工艺 把1,2-二氯丙烷、水、碳酸氢钠和十六烷基三丁基溴化鏻一起加入反应釜内，在100℃二氧化碳分压1.0MPa下反应18h，得到80%的丙二醇。控制二氯丙烷的加料速度，即高温时加料速度快，低温时则慢。实例：在300ml的高压釜内加入60g碳酸钙和150g水，搅拌升温至230℃，以0.03g/(min·100gH2O)的速度连续加入二氯丙烷11.5h；在此温度继续搅拌30min，之后急冷至室温，丙二醇收率约95%。控制温度在130-300℃内，只要相应改变二氯丙烷的投料速度，丙二醇的收率皆可达到95%以上。（二）两步水解工艺 先将原料在釜式反应器内进行反应，二氯丙烷达到一定转化率后，再打料至一活塞流反应器中继续反应，最后水解成丙二醇。实例：将606kg 二氯丙烷加进2立方米反应釜中，再加入800kg乙酸钠、556kg1,2-丙二醇、10kg乙酸和1kg水，搅拌升温至180℃，4h后冷至120℃，抽出物料，经预热器升温至180℃，以500L/h的速度通过一长400m、内径25mm、容积230L的活塞流式反应器，在第2个搅拌釜中收集产物，冷至室温，分析产物为：44kg二氯丙烷、334kg丙二醇、32kg乙酸钠、44kg乙酸、234kg1,2-二乙酰氧基丙烷、693kg丙二醇单乙酸酯、45kg1-氯丙烯、547kgNACL和1kg水。
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丙二醇海关

[ 海关编码 ]: 2905320000

丙二醇文献

Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.

Mol. Pharm. 11(7) , 1991-6, (2014)

Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. H...

The effects of endothelial progenitor cells on rat atherosclerosis.

Biotechnol. Appl. Biochem. 62(2) , 186-92, (2015)

Atherosclerosis (AS) is a progressive disease characterized by endothelial injury and lipid aggregation in the arterial walls. Studies have reported that endothelial progenitor cells (EPCs) derived fr...

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharm. Dev. Technol. 20(2) , 169-75, (2015)

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches....


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相关化合物

【丙二醇】化源网提供丙二醇CAS号57-55-6，丙二醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询丙二醇上化源网，专业又轻松。>>电脑版：丙二醇

标题：丙二醇_MSDS_用途_密度_丙二醇CAS号【57-55-6】_化源网 地址：https://m.chemsrc.com/mip/cas/57-55-6_674628.html