α-甲基-L-酪氨酸

α-甲基-L-酪氨酸用途

Metyrosine 是一种选择性酪氨酸羟化酶 (tyrosine hydroxylase enzyme) 抑制剂。Metyrosine 具有抗炎和抗溃疡作用。Metyrosine 显著抑制高 COX-2 活性。Metyrosine 是一种非常有效的控制血压的药物。

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α-甲基-L-酪氨酸名称

[ CAS 号 ]:
672-87-7

[ 中文名 ]:
α-甲基-L-酪氨酸

[ 英文名 ]:
Metyrosine

[中文别名 ]:

[英文别名 ]:

MFCD00064201
(S)-alpha-Methyltyrosine
α-METHYL-L-P-TYROSINE
alpha-methyl-L-tyrosine
EINECS 211-599-5

α-甲基-L-酪氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> COX

[体外研究]

甲状腺素通过抑制酪氨酸羟化酶起作用,从而导致肾上腺储存的儿茶酚胺耗尽[2]。

[体内研究]

甲状腺素(50-200 mg/kg；i.p.)可减少角叉菜胶炎症[1]。甲状腺素(50-200 mg/kg；i.p.)显示,50、100和200 mg/kg剂量的甲状腺素的抗溃疡活性分别为87.7%、93.7%和95.5%[1]。动物模型：雄性白化Wistar大鼠(角叉菜胶致大鼠足肿胀)[2]剂量：50、100或200 mg/kg给药：I.p.结果：50、100和200 mg/kg给药(分别为40%、67%和87%,4 h)可减轻角叉菜胶炎症。

[参考文献]

[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119.

[2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336.

α-甲基-L-酪氨酸物理化学性质

[ 密度 ]:
1.283g/cm3

[ 沸点 ]:
383.7ºC at 760 mmHg

[ 熔点 ]:
320-340°C dec.

[ 分子式 ]:
C₁₀H₁₃NO₃

[ 分子量 ]:
195.21500

[ 闪点 ]:
185.9ºC

[ 精确质量 ]:
195.09000

[ PSA ]:
83.55000

[ LogP ]:
1.43700

[ 折射率 ]:
1.599

[ 储存条件 ]:
−20°C

α-甲基-L-酪氨酸MSDS

详细MSDS(安全技术说明书)

α-甲基-L-酪氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

α-甲基-L-酪氨酸合成路线

详细合成路线

α-甲基-L-酪氨酸上下游产品

α-甲基-L-酪氨酸上游产品

α-甲基-L-酪氨酸下游产品

α-甲基-L-酪氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

α-甲基-L-酪氨酸文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

FDA-approved drug labeling for the study of drug-induced liver injury.

Drug Discov. Today 16 , 697-703, (2011)

Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...

Effects of intratumoral inflammatory process on 18F-FDG uptake: pathologic and comparative study with 18F-fluoro-α-methyltyrosine PET/CT in oral squamous cell carcinoma.

J. Nucl. Med. 56(1) , 16-21, (2015)

The accurate depiction of both biologic and anatomic profiles of tumors has long been a challenge in PET imaging. An inflammation, which is innate in the carcinogenesis of oral squamous cell carcinoma...

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