α-甲基-L-酪氨酸
α-甲基-L-酪氨酸结构式
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常用名 | α-甲基-L-酪氨酸 | 英文名 | Metyrosine |
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| CAS号 | 672-87-7 | 分子量 | 195.21500 | |
| 密度 | 1.283g/cm3 | 沸点 | 383.7ºC at 760 mmHg | |
| 分子式 | C10H13NO3 | 熔点 | 320-340°C dec. | |
| MSDS | 中文版 美版 | 闪点 | 185.9ºC |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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FDA-approved drug labeling for the study of drug-induced liver injury.
Drug Discov. Today 16 , 697-703, (2011) Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effective approach to discover key DILI mechanisms and risk fact... |
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Effects of intratumoral inflammatory process on 18F-FDG uptake: pathologic and comparative study with 18F-fluoro-α-methyltyrosine PET/CT in oral squamous cell carcinoma.
J. Nucl. Med. 56(1) , 16-21, (2015) The accurate depiction of both biologic and anatomic profiles of tumors has long been a challenge in PET imaging. An inflammation, which is innate in the carcinogenesis of oral squamous cell carcinoma (OSCC), frequently complicates the image analysis because ... |
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Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.
J. Neurosci. 33(26) , 10591-606, (2013) A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrow... |
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The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Croat. Med. J. 53(3) , 214-23, (2012) To elucidate the involvement of noradrenergic system in the mechanism by which diazepam suppresses basal hypothalamic-pituitary-adrenal (HPA) axis activity.Plasma corticosterone and adrenocorticotropic hormone (ACTH) levels were determined in female rats trea... |
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Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test
Behav. Brain Res. 226(2) , 381-5, (2012) Highlights ► Tipepidine produces an antidepressant like effect in the forced swimming test. ► The effect of tipepidine may be produced via dopamine D 1 and alpha2 adrenoceptor. ► The properties of the effect may be different from those of known antidepressant... |
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AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.
Behav. Pharmacol. 23(2) , 171-7, (2012) The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspension test was used with male CF1 albino mice. D,L-α-methyl-ρ... |
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Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms.
J. Neurochem. 125(3) , 373-85, (2013) Amphetamine has well-established actions on pre-synaptic dopamine signaling, such as inhibiting uptake and degradation, activating synthesis, depleting vesicular stores, and promoting dopamine-transporter reversal and non-exocytotic release. Recent in vivo st... |
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The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Surg. Today 42(11) , 1051-60, (2012) To investigate the effects of metyrosine, lacidipine, clonidine, and moxonidine on the renal damage in rats with unilateral ureteral ligation by examining the histological evidence of parenchymal damage and tubular dilatation, as well as biochemical changes i... |
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Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa.
Biol. Psychiatry 37(8) , 1945-52, (2012) Disturbances in reward processing have been implicated in bulimia nervosa (BN). Abnormalities in processing reward-related stimuli might be linked to dysfunctions of the catecholaminergic neurotransmitter system, but findings have been inconclusive. A powerfu... |