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S-亚硝基-N-乙酰-DL-青霉胺

S-亚硝基-N-乙酰-DL-青霉胺用途

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种一氧化氮供体,是一种稳定的血小板聚集抑制剂。

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S-亚硝基-N-乙酰-DL-青霉胺名称

[ CAS 号 ]:
67776-06-1

[ 中文名 ]:
S-亚硝基-N-乙酰-DL-青霉胺

[ 英文名 ]:
N-Acetyl-3-(nitrososulfanyl)valine

[中文别名 ]:

[英文别名 ]:

MFCD00272624
N-Acetyl-3-(nitrososulfanyl)valine
Valine, N-acetyl-3-(nitrosothio)-
snap

S-亚硝基-N-乙酰-DL-青霉胺生物活性

[ 描述 ]:

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种一氧化氮供体,是一种稳定的血小板聚集抑制剂。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[体外研究]

S-亚硝基-N-乙酰-DL-青霉胺(10 mm；8小时)通过释放一氧化氮(NO)1诱导6小时后在常压条件下毒性约80%。S-亚硝基-N-乙酰-DL-青霉胺在离体大鼠心室肌细胞中的半衰期约为6小时[3]。S-亚硝基-N-乙酰-DL-青霉胺(100μM；30分钟)导致离体大鼠心室肌细胞基础pHi持续降低[3]。细胞活力测定(1)细胞系：大鼠肝窦内皮细胞浓度：2 mm,5 mm,10 mm孵育时间：2小时,4小时,6小时,8小时结果：显示对培养内皮细胞的细胞毒性。

[体内研究]

SNAP(100μM,300μM)引起豚鼠气管内电诱发的[3H]-乙酰胆碱释放少量但显著增加[4]。

[参考文献]

[1]. E. Salas, et al. Comparative pharmacology of analogues of S-nitroso-N-acetyl-DL-penicillamine on human platelets. Br J Pharmacol. 1994 Aug;112(4):1071-6.

[2]. Ioannidis I, et al. Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside under hypoxic conditions. Biochem J. 1996 Sep 15;318 ( Pt 3):789-95.

[3]. Pravdic D, et al. Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes. Clin Exp Pharmacol Physiol. 2012 Sep;39(9):772-8.

[4]. Mang CF, et al. Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP). Br J Pharmacol. 2000 Sep;131(1):94-8.

S-亚硝基-N-乙酰-DL-青霉胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
151ºC

[ 分子式 ]:
C₇H₁₂N₂O₄S

[ 分子量 ]:
220.246

[ 精确质量 ]:
220.051773

[ PSA ]:
121.13000

[ LogP ]:
1.13

[ 外观性状 ]:
绿色结晶固体

[ 折射率 ]:
1.560

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: ≥2 mg/mL

S-亚硝基-N-乙酰-DL-青霉胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

S-亚硝基-N-乙酰-DL-青霉胺合成路线

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S-亚硝基-N-乙酰-DL-青霉胺文献

Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions.

PLoS ONE 9(10) , e110020, (2014)

Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the aim of this study was to determine if the ...

Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.

Biochim. Biophys. Acta 1843(11) , 2645-61, (2014)

Interferon-gamma (Ifnγ), a known immunomodulatory cytokine, regulates cell proliferation and survival. In this study, the mechanisms leading to the selective susceptibility of some tumor cells to Ifnγ...

S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth.

Nat. Commun. 6 , 8669, (2015)

Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regula...

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