六甲磷酰三胺(HMPA)
六甲磷酰三胺(HMPA)用途
用作聚氯乙烯及其他含氯树脂制品、涂料的高效耐蚀剂
【用途二】
该品是聚氯乙烯的耐候溶剂和优良的极性溶剂，对农用薄膜的耐低温防老化具有显著效果；它是一种多功能的对质子惰性的高沸点极性溶剂，作为高分子合成的溶剂如聚苯硫醚、芳香族聚酰胺的合成具有特殊效果，该品作为丙烯本体聚合的助催化剂，在乙丙橡胶中添加该品，可以提高弹体和耐油性。六甲基磷酰三胺还用作气相色谱固定液、紫光抑制剂、火箭燃料降低冰点添加剂、化学灭菌剂。
【用途三】
聚氯乙烯的紫外光抑制剂、耐候溶剂和优良的极性溶剂、化学灭菌剂等。
六甲磷酰三胺(HMPA)名称
[ CAS 号 ]:
680-31-9
[ 中文名 ]:
六甲基磷酰三胺
[ 英文名 ]:
Hexamethylphosphoramide
[中文别名 ]:
[英文别名 ]:
- hexamethyl
- HMPTA
- hexamethylphosphoric triamide
- HPT
- hexamethylphosphoric acid triamide
- HEXAMETAPOL
- Hexamethylphosphoramide
- ENT 50,882
- MFCD00008303
- EINECS 211-653-8
六甲磷酰三胺(HMPA)物理化学性质
[ 密度 ]:
1.03 g/mL at 25 °C(lit.)
[ 沸点 ]:
230-232 °C740 mm Hg(lit.)
[ 熔点 ]:
7 °C(lit.)
[ 分子式 ]:
C6H18N3OP
[ 分子量 ]:
179.20000
[ 闪点 ]:
222 °F
[ 精确质量 ]:
179.11900
[ PSA ]:
36.60000
[ LogP ]:
0.77930
[ 外观性状 ]:
透明无色至淡琥珀色液体
[ 蒸汽密度 ]:
6.18 (vs air)
[ 蒸汽压 ]:
0.07 mm Hg ( 25 °C)
[ 折射率 ]:
n20/D 1.459(lit.)
[ 储存条件 ]:
存放于惰性气体之中;避免空气
[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents.
[ 水溶解性 ]:
Miscible
[ 凝固点 ]:
7℃
六甲磷酰三胺(HMPA)MSDS
六甲磷酰三胺(HMPA)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TD0875000
- CHEMICAL NAME :
- Phosphoric triamide, hexamethyl-
- CAS REGISTRY NUMBER :
- 680-31-9
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 101
- MOLECULAR FORMULA :
- C6-H18-N3-O-P
- MOLECULAR WEIGHT :
- 179.24
- WISWESSER LINE NOTATION :
- 1N1&PO&N1&1&N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2650 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - incontinence
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2920 mg/m3/4H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - fasciculations Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2600 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1175 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 835 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6 gm/kg/60D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8640 mg/kg/72D-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - bronchiectasis Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 ppb/6H/32W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4600 mg/kg/92D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1500 mg/kg/21D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 ppb/52W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 ppb/35W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/26W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 ppb/6H/1Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4000 ppb/39W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/6H/26W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 ppb/6H/43W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 ppb/6H/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/6H/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 ppb/6H/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2430 mg/kg
- SEX/DURATION :
- multigenerations
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Heritable translocation test
- TYPE OF TEST :
- Heritable translocation test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Sperm Morphology
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Liver
- REFERENCE :
- PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,397,1985 *** REVIEWS *** ACGIH TLV-Animal carcinogen (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,211,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,211,1977 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-BELGIUM;Skin;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:.;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND;Skin;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4066 No. of Facilities: 92 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 700 (estimated) No. of Female Employees: 51 (estimated)
六甲磷酰三胺(HMPA)安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H340-H350
[ 警示性声明 ]:
P201-P308 + P313
[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R45;R46
[ 安全声明 (欧洲) ]:
S53-S45
[ 危险品运输编码 ]:
2810
[ WGK德国 ]:
3
[ RTECS号 ]:
TD0875000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
六甲磷酰三胺(HMPA)合成路线
六甲磷酰三胺(HMPA)上下游产品
六甲磷酰三胺(HMPA)上游产品
六甲磷酰三胺(HMPA)下游产品
六甲磷酰三胺(HMPA)制备
由二甲胺与碱氯氧磷反应而得。将二甲胺和三氯氧磷在溶剂三氧乙烯中反应，温度控制在40-60℃，反应时加入氨作为缚酸剂，与生成的氯化氢作用成为氯化铵沉淀。反应结束后，过滤。滤液回收三氯乙烯后用碱处理，再进行蒸馏，收集113-118℃（2.0kPa）馏分即得六甲基磷酰三胺。清华紫光集团总公司与生产厂合作开发无溶剂法新工艺产品纯度达99.2以上。工业品六甲基磷酰三胺为无色或淡黄色透明液体。催化剂级含量≥99.5%，一级品≥99.0%，二级品≥98.0%。原料消耗定额：二甲胺2410kg/t、二氯氧磷1610kg/t、液氨430kg/t。
精制方法：与氧化钙一起回流24小时后，在金属钠存在下于0.133Pa压力下蒸馏精制。
六甲磷酰三胺(HMPA)文献
J. Am. Chem. Soc. 136(44) , 15702-10, (2014)
Cationic naked nanocrystals (NCs) are useful building units for assembling hierarchical mesostructured materials. Until now, their preparation required strongly electrophilic reagents that irreversibl...
Modified in vivo comet assay detects the genotoxic potential of 14-hydroxycodeinone, an α,β-unsaturated ketone in oxycodone.Environ. Mol. Mutagen. 56 , 777-87, (2015)
14-Hydroxycodeinone (14-HC) is an α,β-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Co...
Lewis base-catalyzed conjugate reduction and reductive aldol reaction of alpha,beta-unsaturated ketones using trichlorosilane.Chem. Commun. (Camb.) (36) , 4309-11, (2008)
Lewis bases such as Ph3P=O and HMPA catalyze the 1,4-reduction of alpha,beta-unsaturated ketones with trichlorosilane, and because the 1,2-reduction of aldehydes scarcely proceeded under the condition...
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