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硬脂酸

硬脂酸用途

Stearic acid是一种长链膳食饱和脂肪酸,存在于许多动植物油脂中。

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硬脂酸名称

[ CAS 号 ]:
57-11-4

[ 中文名 ]:
硬脂酸

[ 英文名 ]:
stearic acid

[中文别名 ]:

[英文别名 ]:

n-octadecanoic acid
groco59
kam1000
pd185
groco55
groco58
naa173
C18
steraic acid
NAA180

硬脂酸生物活性

[ 描述 ]:

Stearic acid是一种长链膳食饱和脂肪酸,存在于许多动植物油脂中。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 酸和醛

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Shen MC et al. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PLoS One. 2014 Sep 15;9(9):e104083.

[相关活性小分子]

硬脂酸物理化学性质

[ 密度 ]:
0.84

[ 沸点 ]:
361 °C(lit.)

[ 熔点 ]:
67-72 °C(lit.)

[ 分子式 ]:
C₁₈H₃₆O₂

[ 分子量 ]:
284.47700

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
284.27200

[ PSA ]:
37.30000

[ LogP ]:
6.33250

[ 外观性状 ]:
白色固体带有一种温和气味

[ 蒸汽压 ]:
1 mm Hg ( 173.7 °C)

[ 折射率 ]:
1.4299

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
0.1-1 g/100 mL at 23 ºC

硬脂酸MSDS

硬脂酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WI2800000

CHEMICAL NAME :: Stearic acid

CAS REGISTRY NUMBER :: 57-11-4

BEILSTEIN REFERENCE NO. :: 0608585

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C18-H36-O2

MOLECULAR WEIGHT :: 284.54

WISWESSER LINE NOTATION :: QV17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(3),321,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 313 gm/kg/30W-C

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,196,1995 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 17,127,1963 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 69740 No. of Facilities: 31794 (estimated) No. of Industries: 220 No. of Occupations: 159 No. of Employees: 541742 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7032 No. of Facilities: 136 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9034 (estimated) No. of Female Employees: 7670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 69740 No. of Facilities: 34970 (estimated) No. of Industries: 239 No. of Occupations: 165 No. of Employees: 1123118 (estimated) No. of Female Employees: 568888 (estimated)

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硬脂酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26-S16

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WI2800000

[ 海关编码 ]:
2915701000

硬脂酸合成路线

硬脂酸上下游产品

硬脂酸上游产品

硬脂酸下游产品

硬脂酸制备

1. 硬脂酸是自然界广泛存在的一种脂肪酸，几乎所有油脂中都有含量不等的硬脂酸，在动物脂肪中的含量较高，如牛油中含量可达 24% ，植物油中含量较少，茶油为 0.8% ，棕榈油为 6% ，但可可脂中的含量则高达 34% 。工业硬脂酸的生产方法主要有分馏法和压榨法两种。在硬化油中加入分解剂，然后水解得粗脂肪酸，再经水洗、蒸馏、脱色即得成品。同时副产甘油。
(1)分馏法在水解锅中加入棉籽油硬化油6t，水解剂硬脂酸甲酚磺酸和硬脂酸萘磺酸120kg。通入蒸汽至油层透明后，加水4200kg。继续加热至沸，常压下反应7.5h，澄清0.5h，分离下层甘油水。此后再加水解剂120kg，通入蒸汽加热到油层透明后，加水3600kg ，反应约10h，当混合酸价达190mgKOH/g以上时即为水解终点。此后澄清0.5h，分离甘油水后，加盐7g、水3600kg进行水洗。再用盐14kg、水4200kg进行二次水洗涤。第一步洗涤后澄清0.5h，第二步洗涤后澄清2h。分尽下层酸水后，取上层混合脂肪酸备用。将混合脂肪酸2000kg加入蒸馏釜，进行减压分馏，釜温250-255℃，塔温210-220℃，顶温200-210℃,塔顶余压0.53-0.93kpa。进料、出料和排料达平衡后，转入连续操作，进料100%，出料40%，徘料60%。徘料用于制造三级硬脂酸。出料经分析碘值达2mgl/100g以下后，将1000kg硬脂酸和3kg92.5%的硫酸依次投入酸洗锅，煮沸洗涤。割尽酸脚后，取硬脂酸450kg投入脱色锅加热到190℃，并先后加入化学纯碱150ml及干燥白土11kg，然后在105℃左右、减压搅拌下脱色约45min。经压滤、浇盘成型，即得一级硬脂酸。水解过程中分离出来的甘油水，在80-100℃用石灰乳中和，经吸滤浓缩、压滤、真空蒸馏、活性炭脱色和压滤等过程可得精甘油。（2）压榨法以动植物油为原料，在水解剂（如氧化锌）存在下经高压水解、洗涤、减压蒸馏、压榨、漂白结晶等工艺制得一级硬脂酸。（3）在分解剂（苯、萘等磺化混合物）存在下，对硬化油脂、牛油脂或羊油脂进行水解，然后经酸化、蒸馏、压榨、酸洗脱色即得成品。
（4）．用油酸加氢法。
（5）．用合成脂肪酸C10～C20和C18～C20馏分为原料经熔化、酸洗（用1%硫酸）铸型、压榨、熔化、酸洗、脱水结晶制得。 2. 烟草：OR，44；FC，9， 15， 18， 41， 43， 50；OR，26； BU，OR，18；BU，9；OR，19。

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硬脂酸海关

[ 海关编码 ]: 2915701000

[ 中文概述 ]:
HS:2915701000 硬脂酸〔以干燥重量计,纯度在90％及以上〕增值税率:17.0% 退税率:9.0% 监管条件:AB 最低关税:7.0% 普通关税:50.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 硬脂酸和软脂酸的含量

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS:2915701000 stearic acid VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:7.0% General tariff:50.0%

硬脂酸文献

Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

Int. J. Pharm. 476(1-2) , 160-3, (2015)

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesti...

Abiogenic Syntheses of Lipoamino Acids and Lipopeptides and their Prebiotic Significance.

Orig. Life Evol. Biosph. 45 , 427-37, (2015)

Researchers have formed peptide bonds under a variety of presumed prebiotic conditions. Here it is proposed that these same conditions would have also formed amide bonds between fatty acids and amino ...

Structural insights into methanol-stable variants of lipase T6 from Geobacillus stearothermophilus.

Appl. Microbiol. Biotechnol. 99 , 9449-61, (2015)

Enzymatic production of biodiesel by transesterification of triglycerides and alcohol, catalyzed by lipases, offers an environmentally friendly and efficient alternative to the chemically catalyzed pr...

更多文献

硬脂酸相关知识

硬脂酸的功效与作用

2018-11-07 16:16:46

硬脂酸是一种结构复杂的化学物质，又被称为十八烷酸，分子式C18H36O2，由油脂水解生产，主要用于生产硬脂酸盐。是构成动、植物油脂的一种主要成分。可用于药物制剂、油膏、肥皂和栓剂等产品。工业品呈白色或微黄色颗粒或块，为45%硬脂酸与55%软脂酸的混合物，并含有少量油酸，略带脂肪气味。工业品的硬脂...

硬脂酸

硬脂酸用途

硬脂酸名称

硬脂酸生物活性

硬脂酸物理化学性质

硬脂酸MSDS

详细MSDS(安全技术说明书)

硬脂酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硬脂酸安全信息

硬脂酸合成路线

详细合成路线

硬脂酸上下游产品

硬脂酸上游产品

硬脂酸下游产品

硬脂酸制备

硬脂酸海关

硬脂酸文献

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硬脂酸相关知识

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