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喷他霉素

喷他霉素用途

Lagosin(Fungichromin)是一种多烯大环内酯类抗生素。Lagosin具有广谱抗真菌活性,不受耐药性影响[1]。

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喷他霉素名称

[ CAS 号 ]:
6834-98-6

[ 中文名 ]:
喷他霉素

[ 英文名 ]:
Lagosin

[英文别名 ]:

Pentamycin
S 232
14-Hydroxyfilipin
Cogomycin
Antibiotic A-246
Lagosin (antibiotic)
EINECS 229-913-4
Lagosin
Fungichromin

喷他霉素生物活性

[ 描述 ]:

Lagosin(Fungichromin)是一种多烯大环内酯类抗生素。Lagosin具有广谱抗真菌活性,不受耐药性影响[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗感染 >> 真菌

[体外研究]

大别山松内生菌链霉菌WP-1产生Lagosin及其对尖孢镰刀菌的抗真菌活性[1]。

[参考文献]

[1]. Peng C, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020;104(24):10437-10449.

喷他霉素物理化学性质

[ 密度 ]:
1.196g/cm3

[ 沸点 ]:
914ºC at 760 mmHg

[ 分子式 ]:
C₃₅H₅₈O₁₂

[ 分子量 ]:
670.83

[ 闪点 ]:
278.4ºC

[ 精确质量 ]:
670.39300

[ PSA ]:
228.60000

[ LogP ]:
0.85880

[ 折射率 ]:
1.545

喷他霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT3850000

CHEMICAL NAME :: Fungichromin

CAS REGISTRY NUMBER :: 6834-98-6

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C35-H58-O12

MOLECULAR WEIGHT :: 670.93

WISWESSER LINE NOTATION :: T-28-OV RU TU VU A&U C&UTJ CYQ5 DQ FQ HQ JQ LQ NQ OQ PQ R1 E&Q F&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1624 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,26,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,716,1954/1955