腺苷5'-二磷酸核糖钠盐

腺苷5'-二磷酸核糖钠盐用途

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物,也是一种最有效和最主要的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂,还可以增强自噬 (autophagy)。

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腺苷5'-二磷酸核糖钠盐名称

[ CAS 号 ]:
68414-18-6

[ 中文名 ]:
腺苷5’-二磷酸核糖钠

[ 英文名 ]:
Adenosine 5′-diphosphoribose sodium

[中文别名 ]:

腺苷5'-二磷酸核糖钠

[英文别名 ]:

Adenosine 5'-diphosphoribose sodium salt
MFCD00136017

腺苷5'-二磷酸核糖钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 内分泌

信号通路 >> 自噬 >> 自噬

研究领域 >> 代谢疾病

[ 靶点 ]

TRPM2 channel[1][2] Autophagy[1]

[体外研究]

在小鼠胚胎成纤维细胞(MEFs)中,H2O2处理表明,聚(ADP-核糖)(PAR)聚合酶-1(PARP-1)的激活产生腺苷5’-二磷酸核糖(ADP-核糖),这是对TrPM2通道的激活信号,从而通过细胞外Ca2+内流和(或)溶酶体Ca2+释放促进Ca2+升高。这一过程最终激活早期或晚期自噬,以应对不同程度的氧化应激[1][1]。TRPM2通道通过腺苷5′-二磷酸核糖(ADP核糖)与TRPM2特有的细胞内NUDT9同源结构域(NUDT9-H)结合而激活,NUDT9同源结构域位于TRPM2的C末端。除ADPR外,细胞内Ca2+是一个重要的协同激活因子：TRPM2通道仅在两种配体的共同存在下开放[2]。

[参考文献]

[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62.

[2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.

腺苷5'-二磷酸核糖钠盐物理化学性质

[ 分子式 ]:
C₁₅H₂₂N₅NaO₁₄P₂

[ 分子量 ]:
581.29800

[ 精确质量 ]:
581.05400

[ PSA ]:
313.97000

[ 储存条件 ]:
-20°C

腺苷5'-二磷酸核糖钠盐MSDS

详细MSDS(安全技术说明书)

腺苷5'-二磷酸核糖钠盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

腺苷5'-二磷酸核糖钠盐文献

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