N6-乙烯基2'-脱氧腺苷

N6-乙烯基2'-脱氧腺苷用途

N6-Etheno 2'-deoxyadenosine 是一种由活性氧/活性氮诱导的 DNA 氧化损伤产物,可作为一种生物指标,来评估动物或人组织中慢性炎症和脂质过氧化。

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N6-乙烯基2'-脱氧腺苷名称

[ CAS 号 ]:
68498-25-9

[ 中文名 ]:
N6-乙烯基2'-脱氧腺苷

[ 英文名 ]:
N6-Etheno 2'-deoxyadenosine

[英文别名 ]:

1,N6-Etheno-2'-deoxyadenosine
1,N6-ETHENO-2'-DEOXY-ADENOSINE

N6-乙烯基2'-脱氧腺苷生物活性

[ 描述 ]:

N6-Etheno 2'-deoxyadenosine 是一种由活性氧/活性氮诱导的 DNA 氧化损伤产物,可作为一种生物指标,来评估动物或人组织中慢性炎症和脂质过氧化。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 炎症/免疫

[参考文献]

[1]. Gao L, et al. DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Chem Res Toxicol. 2017 Mar 20;30(3):794-803.

N6-乙烯基2'-脱氧腺苷物理化学性质

[ 密度 ]:
1.85 g/cm3

[ 分子式 ]:
C₁₂H₁₃N₅O₃

[ 分子量 ]:
275.26300

[ 精确质量 ]:
275.10200

[ PSA ]:
97.70000

[ 折射率 ]:
1.876

N6-乙烯基2'-脱氧腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

N6-乙烯基2'-脱氧腺苷合成路线

详细合成路线

N6-乙烯基2'-脱氧腺苷上下游产品

N6-乙烯基2'-脱氧腺苷上游产品

N6-乙烯基2'-脱氧腺苷下游产品

N6-乙烯基2'-脱氧腺苷文献

In vitro synthesis of 1,N6-etheno-2'-deoxyadenosine and 1,N2-etheno-2'-deoxyguanosine by 2,4-dinitrophenol and 1,3-dinitropyrene in presence of a bacterial nitroreductase.

Environ. Toxicol. 22(2) , 222-7, (2007)

The formation of covalent nitro-PAH DNA adducts and nitro-PAH mediated oxidative lesions are two possible mechanisms for the initiation of nitro-PAH carcinogenesis. Sixty-minute incubation of 1,3-dini...

Urinary level of 1,N(6) -ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and omega 6-polyunsaturated fatty acid intake in postmenopausal Japanese women.

Int. J. Cancer 100(1) , 71-5, (2002)

Excretion of 1,N(6)-ethenodeoxyadenosine (epsilon dA), a marker for lipid peroxidation (LPO)-derived DNA damage was analyzed in urine of nonsmoking postmenopausal women participating in a dietary inte...

Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study.

Free Radic. Res. 39(1) , 51-3, (2005)

Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and...

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