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2’-脱氧胞苷

2’-脱氧胞苷用途

2'-Deoxycytidine,一个脱氧和苷,能够抑制 Brdu 的生物活性。

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2’-脱氧胞苷名称

[ CAS 号 ]:
951-77-9

[ 中文名 ]:
2'-脱氧胞嘧啶核苷

[ 英文名 ]:
2'-Deoxycytidine monohydrate

[中文别名 ]:

[英文别名 ]:

1-(2-Deoxy-β-D-ribofuranosyl)cytosine
EINECS 213-454-1
Cytidine, 2'-deoxy-
1-(2-Deoxy-b-D-ribofuranosyl)cytosine
deoxycytidine
2'-Deoxycytidine monohydrate
2‘-Deoxycytidine
1-(2-deoxy-β-D-erythro-pentofuranosyl)-Cytosine
MFCD00006547

2’-脱氧胞苷生物活性

[ 描述 ]:

2'-Deoxycytidine,一个脱氧和苷,能够抑制 Brdu 的生物活性。

[ 相关类别 ]:

天然产物 >> 糖和糖苷

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

Brdu

[参考文献]

[1]. Horn D, et al. Inhibition of biological effects of bromodeoxyuridine by deoxycytidine: correlation with decreased incorporation of bromodeoxyuridine into DNA. Somatic Cell Genet. 1976 Sep;2(5):469-81.

[相关活性小分子]

2’-脱氧胞苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
482.1±55.0 °C at 760 mmHg

[ 熔点 ]:
209-211 °C(lit.)

[ 分子式 ]:
C₉H₁₃N₃O₄

[ 分子量 ]:
227.22

[ 闪点 ]:
245.4±31.5 °C

[ PSA ]:
119.83000

[ LogP ]:
-1.73

[ 外观性状 ]:
细灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.720

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless

2’-脱氧胞苷MSDS

详细MSDS(安全技术说明书)

2’-脱氧胞苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA3800000

CHEMICAL NAME :: Cytidine, 2'-deoxy-

CAS REGISTRY NUMBER :: 951-77-9

BEILSTEIN REFERENCE NO. :: 0087567

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H13-N3-O4

MOLECULAR WEIGHT :: 227.25

WISWESSER LINE NOTATION :: T6NVNJ DZ A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 800 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

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2’-脱氧胞苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HA3800000

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2’-脱氧胞苷文献

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.

Anal. Bioanal. Chem 407(13) , 3693-704, (2015)

Nucleosides and nucleoside triphosphates are the building blocks of nucleic acids and important bioactive metabolites, existing in all living cells. In the present study, two liquid chromatography tan...

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.

Bioorg. Med. Chem. 16 , 3866-70, (2008)

Thymidine phosphorylase (TP, EC 2.4.2.4) recognized the structure of the substrate with high specificity, via both the base and the ribosyl moieties. The replacement of 3'-OH of thymidine markedly inf...

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