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非阿尿苷

非阿尿苷用途

Fialuridine是一种具有抗病毒活性的核苷类似物。

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非阿尿苷名称

[ CAS 号 ]:
69123-98-4

[ 中文名 ]:
非阿尿苷

[ 英文名 ]:
Fialuridine

[中文别名 ]:

5-碘-2'-氟脱氧尿苷

[英文别名 ]:

Fialuridine
5-Iodo-2'-fluoroarauracil
2'-Deoxy-2'-fluoro-5-iodouridine

非阿尿苷生物活性

[ 描述 ]:

Fialuridine是一种具有抗病毒活性的核苷类似物。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[参考文献]

[1]. Mansuri MM, et al. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71.

非阿尿苷物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 熔点 ]:
216-217ºC

[ 分子式 ]:
C₉H₁₀FIN₂O₅

[ 分子量 ]:
372.09

[ 精确质量 ]:
371.961823

[ PSA ]:
104.55000

[ LogP ]:
-0.32

[ 外观性状 ]:
无色晶体

[ 折射率 ]:
1.685

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
DMSO: soluble5mg/mL, clear (warmed)

非阿尿苷MSDS

非阿尿苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9512500

CHEMICAL NAME :: Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-

CAS REGISTRY NUMBER :: 69123-98-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-I-N2-O5

MOLECULAR WEIGHT :: 372.11

WISWESSER LINE NOTATION :: T6NVMVJ EI A- BT5OTJ CF DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 9100 ug/kg/13W-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 40 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982

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非阿尿苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
YQ9512500

[ 海关编码 ]:
2934999090

非阿尿苷合成路线

非阿尿苷上下游产品

非阿尿苷上游产品

非阿尿苷下游产品

非阿尿苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

非阿尿苷文献

Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU).

Nucl. Med. Biol. 37(4) , 439-42, (2010)

An improved synthesis of 2'-[(18)F]-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ([(18)F]-FIAU) has been developed. The method utilizes trimethylsilyl trifluoromethanesulfonate (TMSOTf) cata...

Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.

Int. J. Med. Microbiol. 302(2) , 101-7, (2012)

The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk)...

Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model.

Cancer Lett. 291(1) , 83-9, (2010)

The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for the MDR1 gene (shMDR) was proposed previously. We investigated the antitumor effects in an ...

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