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5-氟乳清酸

5-氟乳清酸用途

5-Fluoroorotic 是酵母分子遗传学中的一种选择剂。 5-Fluoroorotic 具有与 5-fluorocytosine 接近的抗癌作用以及中等程度的抗皮肤癣菌作用。

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5-氟乳清酸名称

[ CAS 号 ]:
703-95-7

[ 中文名 ]:
5-氟乳清酸

[ 英文名 ]:
5-Fluoroorotic acid

[中文别名 ]:

5-氟乳清酸水合物

[英文别名 ]:

EINECS 211-876-0
5-Fluoro-6-carboxyuracil
5-Fluoro orotic acid
MFCD00042526
Orotic acid, 5-fluoro-
5-Fluoroorotic acid
5-Fluoroorotic acid monohydrate

5-氟乳清酸生物活性

[ 描述 ]:

5-Fluoroorotic 是酵母分子遗传学中的一种选择剂。 5-Fluoroorotic 具有与 5-fluorocytosine 接近的抗癌作用以及中等程度的抗皮肤癣菌作用。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75.

[2]. Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9(2): 85-9.

5-氟乳清酸物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 熔点 ]:
278 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₃FN₂O₄

[ 分子量 ]:
174.087

[ 精确质量 ]:
174.007690

[ PSA ]:
103.02000

[ LogP ]:
-1.00

[ 外观性状 ]:
淡黄色或红黄色、晶体或粉末

[ 折射率 ]:
1.580

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
NH4OH 4 M: 50 mg/mL, clear, faintly yellow

5-氟乳清酸MSDS

详细MSDS(安全技术说明书)

5-氟乳清酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV7800000

CHEMICAL NAME :: 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-

CAS REGISTRY NUMBER :: 703-95-7

LAST UPDATED :: 198605

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H3-F-N2-O4

MOLECULAR WEIGHT :: 174.10

WISWESSER LINE NOTATION :: T6VMVMJ EVQ FF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 981 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

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5-氟乳清酸安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ WGK德国 ]:
3

[ RTECS号 ]:
UV7800000

[ 海关编码 ]:
2933599090

5-氟乳清酸上下游产品

5-氟乳清酸上游产品

5-氟乳清酸下游产品

5-氟乳清酸海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%