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鞘丝藻毒素 a

鞘丝藻毒素 a用途

Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。

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鞘丝藻毒素 a名称

[ CAS 号 ]:
70497-14-2

[ 中文名 ]:
鞘丝藻毒素 a

[ 英文名 ]:
Teleocidin A1

[英文别名 ]:

lyngbyatoxin
teleocidina
Teleocicin A-1
lyngbyatoxin A (teleocidin A-1)
teleocidin A1

鞘丝藻毒素 a生物活性

[ 描述 ]:

Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 癌症

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

[参考文献]

[1]. Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A). Food Chem Toxicol. 1992;30(9):795-801.

[2]. Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29(8):703-709.

鞘丝藻毒素 a物理化学性质

[ 密度 ]:
1.06 g/cm3

[ 沸点 ]:
665.1ºC at 760 mmHg

[ 分子式 ]:
C₂₇H₃₉N₃O₂

[ 分子量 ]:
437.61700

[ 闪点 ]:
356ºC

[ 精确质量 ]:
437.30400

[ PSA ]:
68.36000

[ LogP ]:
5.24580

鞘丝藻毒素 a毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WY1981000

CHEMICAL NAME :: 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-9-(1-ethenyl-1,5- dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-m ethylethyl)-

CAS REGISTRY NUMBER :: 70497-14-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H39-N3-O2

MOLECULAR WEIGHT :: 437.69

WISWESSER LINE NOTATION :: T569 1A O DM JN LVM&&TJ FX1&1U1&3UY1&1 J1 KY1&1 N1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,636,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 204,193,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 26,660,1962