甲氧苄氨嘧啶

甲氧苄氨嘧啶用途

Trimethoprim是抗菌素,可作用于泌尿系统感染。

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甲氧苄氨嘧啶作用

用途一：作为抗菌增效药，也可以治疗家禽细菌感染和球虫病。
用途二：新型口服广谱抗菌药物。抗菌谱与磺胺药物相似而效力较强，对多种革兰氏阳性和阴性细菌有效。由于细菌对本品将易产生耐药性，故不宜单独作为抗菌药使用。甲氧苄啶与磺胺药合用可使抗菌作用增强数倍至数十倍。该品主要作磺安类药的增效药。一般按1：5的比例使用。也可作为兽药，治疗禽率大肠肝菌引起的败血症，鸡白痢，禽伤寒，霍乱，呼吸系统继发性细菌感染等。还可用于球虫病的治疗。
用途三：抗菌增效药，单独用于呼吸道感染、泌尿道感染、肠道感染等病症

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甲氧苄氨嘧啶名称

[ CAS 号 ]:
738-70-5

[ 中文名 ]:
甲氧苄啶

[ 英文名 ]:
Trimethoprim

[中文别名 ]:

甲氧苄氨嘧啶

[英文别名 ]:

EINECS 212-006-2
Trimanyl
Triprim
Instalac
Trimethoprim
Monotrimin
MFCD00036761
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
Trimogal
WELLCOPRIM

甲氧苄氨嘧啶生物活性

[ 描述 ]:

Trimethoprim是抗菌素,可作用于泌尿系统感染。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 叶酸

研究领域 >> 炎症/免疫

[参考文献]

[1]. Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47(4): p. 286-9.

[2]. Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23(6): p. 405-30.

[相关活性小分子]

甲氧苄氨嘧啶物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
405.2±55.0 °C at 760 mmHg

[ 熔点 ]:
199-203 °C

[ 分子式 ]:
C₁₄H₁₈N₄O₃

[ 分子量 ]:
290.318

[ 闪点 ]:
198.8±31.5 °C

[ 精确质量 ]:
290.137878

[ PSA ]:
105.51000

[ LogP ]:
0.38

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, acids.

[ 水溶解性 ]:
DMSO: soluble | <0.1 g/100 mL at 24 ºC

甲氧苄氨嘧啶MSDS

详细MSDS(安全技术说明书)

甲氧苄氨嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8225000

CHEMICAL NAME :: Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-

CAS REGISTRY NUMBER :: 738-70-5

BEILSTEIN REFERENCE NO. :: 0625127

LAST UPDATED :: 199703

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C14-H18-N4-O3

MOLECULAR WEIGHT :: 290.36

WISWESSER LINE NOTATION :: T6N CNJ BZ DZ E1R CO1 DO1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 56 mg/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Blood - other changes Musculoskeletal - joints

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 60 mg/kg/10D-I

TOXIC EFFECTS :: Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2764 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1870 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31800 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 27300 mg/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 31800 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2250 mg/kg

SEX/DURATION :: female 11-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/8D

REFERENCE :: JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 112,348,1974 *** REVIEWS *** TOXICOLOGY REVIEW HFHBAG Hartford Hospital Bulletin. (Hartford Hospital, 80 Seymour St., Hartford, CT 06115) V.1- 1938/39- Volume(issue)/page/year: 29,364,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4630 No. of Facilities: 918 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 21309 (estimated) No. of Female Employees: 16105 (estimated)

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甲氧苄氨嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
UV8225000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933599090

甲氧苄氨嘧啶上下游产品

甲氧苄氨嘧啶上游产品

甲氧苄氨嘧啶下游产品

甲氧苄氨嘧啶制备

可由没食子酸和硝酸胍等合成。

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甲氧苄氨嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甲氧苄氨嘧啶文献

Experimental study of the impact of antimicrobial treatments on Campylobacter, Enterococcus and PCR-capillary electrophoresis single-strand conformation polymorphism profiles of the gut microbiota of chickens.

J. Med. Microbiol. 63(Pt 11) , 1552-60, (2014)

An experiment was conducted to compare the impact of antimicrobial treatments on the susceptibility of Campylobacter, Enterococcus faecium and Enterococcus faecalis, and on the diversity of broiler mi...

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.

J. Chromatogr. A. 1418 , 140-9, (2015)

The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of...

更多文献

甲氧苄氨嘧啶

甲氧苄氨嘧啶用途

甲氧苄氨嘧啶作用

甲氧苄氨嘧啶名称

甲氧苄氨嘧啶生物活性

甲氧苄氨嘧啶物理化学性质

甲氧苄氨嘧啶MSDS

详细MSDS(安全技术说明书)

甲氧苄氨嘧啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

甲氧苄氨嘧啶安全信息

甲氧苄氨嘧啶上下游产品

甲氧苄氨嘧啶上游产品

甲氧苄氨嘧啶下游产品

甲氧苄氨嘧啶制备

甲氧苄氨嘧啶海关

甲氧苄氨嘧啶文献

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