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3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮

用途

吡伦哌酮(R 47465)是一种5-HT2血清素受体拮抗剂。吡仑贝隆具有适度的抗焦虑活性[1][2]。
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名称

[ CAS 号 ]:
75444-65-4

[ 中文名 ]:
哌南氟酮

[ 英文名 ]:
Pirenperone

[英文别名 ]:

生物活性

[ 描述 ]:

吡伦哌酮(R 47465)是一种5-HT2血清素受体拮抗剂。吡仑贝隆具有适度的抗焦虑活性[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
信号通路 >> 神经信号通路 >> 5-HT受体

[参考文献]

[1]. Krstić MK, et, al. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Arch Int Physiol Biochim. 1983 Nov;91(4):345-9.

[2]. Ansseau M, et, al. Pilot study of a specific serotonergic antagonist, pirenperone, in the treatment of anxiety disorders. Acta Psychiatr Belg. Sep-Oct 1983;83(5):517-24.

物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
556.3ºC at 760 mmHg

[ 分子式 ]:
C23H24FN3O2

[ 分子量 ]:
393.45

[ 闪点 ]:
290.2ºC

[ 精确质量 ]:
393.18500

[ PSA ]:
54.68000

[ LogP ]:
3.21730

[ 折射率 ]:
1.629

[ 储存条件 ]:
室温，干燥，密封

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

合成路线

详细合成路线

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文献

5-HT inhibits spontaneous contractility of isolated sheep mesenteric lymphatics via activation of 5-HT(4) receptors.

Microvasc. Res. 60(3) , 261-8, (2000)

Spontaneous isometric contractions were measured in rings of sheep mesenteric lymphatic vessels in vitro. 5-Hydroxytryptamine (5-HT) produced a concentration-dependent decrease in spontaneous contract...

Monoamine systems in the discriminative effects of spiradoline, a kappa-opioid agonist.

Pharmacol. Biochem. Behav. 47(3) , 575-8, (1994)

The results of studies on mice indicate that the antinociceptive effects of kappa-opioid agonists are due, in part, to activation of the 5-HT2 type of serotonin receptor. One objective of this study w...

Visual recognition memory in squirrel monkeys: effects of serotonin antagonists on baseline and hypoxia-induced performance deficits.

Pharmacol. Biochem. Behav. 39(4) , 991-6, (1991)

Cognitive deficits resulting from neuropathological brain changes such as Alzheimer's Disease or normal aging are most likely due to alterations in multiple neurotransmitter systems. While the majorit...


更多文献

推荐生产厂家/供应商：

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥648.9/5mg ￥7136.9/100mg ￥2265.9/25mg ￥需询单/1g

联系人：阿拉丁李高志

产品详情：肾上腺素

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3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮供应商

热门化合物

CAS号[75444-65-4]化源网提供[3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮

标题：75444-65-4_CAS号:75444-65-4_3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮 - 化源网 地址：https://m.chemsrc.com/mip/cas/75444-65-4_603389.html