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2',7'-二氯荧光素

2',7'-二氯荧光素用途

2’,7’-二氯荧光素作为荧光探针(Ex=496nm,Em=525nm)用于活性氧(ROS)测量[1]。

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2',7'-二氯荧光素名称

[ CAS 号 ]:
76-54-0

[ 中文名 ]:
2′,7′-二氯荧光素

[ 英文名 ]:
dichlorofluorescein

[中文别名 ]:

[英文别名 ]:

EINECS 200-968-6
dichlorofluorescein
2‘,7‘-Dichlorofluorescein
MFCD00005047

2',7'-二氯荧光素生物活性

[ 描述 ]:

2’,7’-二氯荧光素作为荧光探针(Ex=496nm,Em=525nm)用于活性氧(ROS)测量[1]。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Reiniers MJ, et al. Preparation and Practical Applications of 2',7'-Dichlorodihydrofluorescein in Redox Assays. Anal Chem. 2017 Apr 4;89(7):3853-3857.

[2]. Xiuping Chen, et al. 2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy. Free Radic Res. 2010 Jun;44(6):587-604.

2',7'-二氯荧光素物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
634.4±55.0 °C at 760 mmHg

[ 熔点 ]:
280 °C (dec.)(lit.)

[ 分子式 ]:
C₂₀H₁₀Cl₂O₅

[ 分子量 ]:
401.196

[ 闪点 ]:
337.4±31.5 °C

[ 精确质量 ]:
399.990540

[ PSA ]:
75.99000

[ LogP ]:
4.10

[ 外观性状 ]:
橙色-黄色固体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.797

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
可溶于：氢氧化钠水溶液；微溶：乙醇

2',7'-二氯荧光素MSDS

2',7'-二氯荧光素安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 1219 3/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NT8050000

[ 危险类别 ]:
3.0

[ 海关编码 ]:
3204200000

2',7'-二氯荧光素合成路线

2',7'-二氯荧光素上下游产品

2',7'-二氯荧光素上游产品

2',7'-二氯荧光素下游产品

2',7'-二氯荧光素制备

由间苯二酚与苯酐单独或在ZnCl2或H2SO4存在下缩合制得。

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2',7'-二氯荧光素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2',7'-二氯荧光素文献

Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.

Toxicol. In Vitro 29(3) , 417-25, (2015)

Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the p...

SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas.

Mol. Cancer 14 , 78, (2015)

High toxicity, morbidity and secondary malignancy render chemotherapy of neuroblastoma inefficient, prompting the search for novel compounds. Nanovesicles offer great promise in imaging and treatment ...

Luteolin-induced protection of H₂O₂-induced apoptosis in PC12 cells and the associated pathway.

Mol. Med. Report. 12 , 7699-704, (2015)

Increasing evidence has indicated that the generation of reactive oxygen species (ROS) contributes to H2O2‑induced nerve injury. This may result in oxidative stress that leads to cell damage or death....

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