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2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈

用途

SCH28080 是钾竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。有抗分泌和细胞保护活性。

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名称

[ CAS 号 ]:
76081-98-6

[ 中文名 ]:
SCH28080

[ 英文名 ]:
SCH 28080

[英文别名 ]:

MFCD00834620

生物活性

[ 描述 ]:

SCH28080 是钾竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。有抗分泌和细胞保护活性。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> 质子泵

[ 靶点 ]

IC50: 20 nM (H+/K+-ATPase, rabbit microsomal membranes)[1]

[参考文献]

[1]. Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.

[2]. Long JF, et al. Gastric antisecretory and cytoprotective activities of SCH 28080. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

物理化学性质

[ 密度 ]:
1.16g/cm3

[ 分子式 ]:
C₁₇H₁₅N₃O

[ 分子量 ]:
277.32

[ 精确质量 ]:
277.12200

[ PSA ]:
50.32000

[ LogP ]:
3.28778

[ 外观性状 ]:
白色至浅棕固体

[ 折射率 ]:
1.615

[ 储存条件 ]:
-20°C

MSDS

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

合成路线

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[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K(+) cycling and to active Na(+) extrusion.

Biochim. Biophys. Acta 1830(8) , 4265-73, (2013)

Orthophosphate (Pi) is a central compound in the metabolism of all organisms, including parasites. There are no reports regarding the mechanisms of Pi acquisition by Trypanosoma cruzi.(32)Pi influx wa...

Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.

PLoS ONE 7(12) , e51451, (2012)

Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers ...

Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.

Am. J. Physiol. Gastrointest. Liver Physiol. 292(3) , G711-7, (2007)

We have previously shown that stimulation of acid secretion in parietal cells causes rapid initial cell shrinkage, followed by Na(+)/H(+) exchange-mediated regulatory volume increase (RVI). The factor...

更多文献

2-(8-(苄氧基)-2-甲基咪唑并[1,2-a]吡啶-3-基)乙腈

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

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上游产品

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海关

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