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DL-2-氨基-5-膦酰基缬草酸

DL-2-氨基-5-膦酰基缬草酸用途

DL-AP5是一种NMDA(N-甲基-D-天冬氨酸)受体拮抗剂。DL-AP5具有明显的抗伤害活性。DL-AP5特异性阻断兔视网膜的通道[1][2]。

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DL-2-氨基-5-膦酰基缬草酸名称

[ CAS 号 ]:
76326-31-3

[ 中文名 ]:
DL-2-氨基-5-膦酰基戊酸

[ 英文名 ]:
DL-AP5

[英文别名 ]:

UNII:39PJ29YY8Z
DL-2-amino-5-phosphonovaleric acid
D-2-amino-5-phosphonovaleric acid
APV
AP-5
DL-AP5
DL-APV
5-Phosphononorvaline
MFCD00010515
2-amino-5-phosphopentanoicacid

DL-2-氨基-5-膦酰基缬草酸生物活性

[ 描述 ]:

DL-AP5是一种NMDA(N-甲基-D-天冬氨酸)受体拮抗剂。DL-AP5具有明显的抗伤害活性。DL-AP5特异性阻断兔视网膜的通道[1][2]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Murray CW, Cowan A, Larson AA. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185.

[2]. Massey SC, Miller RF. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30.

DL-2-氨基-5-膦酰基缬草酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
482.1±55.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₁₂NO₅P

[ 分子量 ]:
197.13

[ 闪点 ]:
245.4±31.5 °C

[ 精确质量 ]:
197.045303

[ PSA ]:
130.66000

[ LogP ]:
-2.32

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
NH4OH 1 M: 50 mg/mL, clear, colorless

DL-2-氨基-5-膦酰基缬草酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2931900090

DL-2-氨基-5-膦酰基缬草酸海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

DL-2-氨基-5-膦酰基缬草酸文献

Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation.

Learn. Mem. 21(11) , 606-15, (2014)

Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previousl...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Anatomical and electrophysiological changes in striatal TH interneurons after loss of the nigrostriatal dopaminergic pathway.

Brain Struct. Funct. 220(1) , 331-49, (2015)

Using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the tyrosine hydroxylase (TH) promoter, we have previously shown that there are approximately 3,000 st...

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