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N-(3-氧代己酰)-DL-高丝氨酸内酯

N-(3-氧代己酰)-DL-高丝氨酸内酯用途

N-(Ketocaproyl)-D,L-homoserine lactone 是 LuxR 的天然配体。N-(Ketocaproyl)-D,L-homoserine lactonesh 是群体感应 (QS) 自动诱导剂。

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N-(3-氧代己酰)-DL-高丝氨酸内酯名称

[ CAS 号 ]:
76924-95-3

[ 中文名 ]:
N-(3-氧代己酰)-DL-高丝氨酸内酯

[ 英文名 ]:
N-(Ketocaproyl)-D,L-homoserine lactone

[英文别名 ]:

n-(ketocaproyl)-d,l-homoserine lactone
N-(3-oxohexanoyl)-L-homoserine lactone
3-Oxo-N-[(3S)-2-oxotetrahydro-3-furanyl]hexanamide

N-(3-氧代己酰)-DL-高丝氨酸内酯生物活性

[ 描述 ]:

N-(Ketocaproyl)-D,L-homoserine lactone 是 LuxR 的天然配体。N-(Ketocaproyl)-D,L-homoserine lactonesh 是群体感应 (QS) 自动诱导剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

N-(酮己基)-D,L-高丝氨酸内酯是费氏弧菌L和D异构体的天然配体[1]。

[参考文献]

[1]. Li SZ, et al. Influence of the d/l configuration of N-acyl-homoserine lactones (AHLs) and analogues on their Lux-R dependent quorum sensing activity. Bioorg Chem. 2018 Apr;77:215-222.

N-(3-氧代己酰)-DL-高丝氨酸内酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
482.9±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₅NO₄

[ 分子量 ]:
213.230

[ 闪点 ]:
245.9±28.7 °C

[ 精确质量 ]:
213.100113

[ PSA ]:
72.47000

[ LogP ]:
-1.17

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.486

[ 储存条件 ]:
−20°C

N-(3-氧代己酰)-DL-高丝氨酸内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

N-(3-氧代己酰)-DL-高丝氨酸内酯文献

Substrate specificity and function of the pheromone receptor AinR in Vibrio fischeri ES114.

J. Bacteriol. 195(22) , 5223-32, (2013)

Two distinct but interrelated pheromone-signaling systems, LuxI/LuxR and AinS/AinR, positively control bioluminescence in Vibrio fischeri. Although each system generates an acyl-homoserine lactone (AH...

Attenuation of Vibrio fischeri quorum sensing using rationally designed polymers.

Biomacromolecules 11(4) , 975-80, (2010)

A first attempt to attenuate the quorum sensing (QS) of a marine heterotroph microorganism, Vibrio fischeri , using signal molecule-sequestering polymers (SSPs) is presented. A set of rationally desig...

The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF.

PLoS ONE 4(8) , e6820, (2009)

Many bacteria produce and respond to the quorum sensing signal autoinducer-2 (AI-2). Escherichia coli and Salmonella typhimurium are among the species with the lsr operon, an operon containing AI-2 tr...

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