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N-3-氧-己酰高丝氨酸内酯

N-3-氧-己酰高丝氨酸内酯用途

N-(β-酮己基)-L-高丝氨酸内酯是群体调节感应的一种成分[1]。

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N-3-氧-己酰高丝氨酸内酯名称

[ CAS 号 ]:
143537-62-6

[ 中文名 ]:
N-3-氧-己酰高丝氨酸内酯

[ 英文名 ]:
N-(3-Oxohexanoyl)homoserine lactone

[英文别名 ]:

3-Oxo-N-(2-oxotetrahydrofuran-3-yl)hexanamide
N-(3-Oxohexanoyl)homoserine lactone
N-(3-Oxohexanoyl)-3-aminodihydro-2(3H)-furanone
Hexanamide, 3-oxo-N-(tetrahydro-2-oxo-3-furanyl)-
3-Oxo-N-(tetrahydro-2-oxo-3-furanyl)hexanamide
3-Oxo-N-(2-oxotetrahydro-3-furanyl)hexanamide
N-(β-ketocaproyl)-DL-homoserine lactone
N-(BETA-KETOCAPROYL)-DL-HOMOSERINE LACTONE

N-3-氧-己酰高丝氨酸内酯生物活性

[ 描述 ]:

N-(β-酮己基)-L-高丝氨酸内酯是群体调节感应的一种成分[1]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Welch M, et al. N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia. EMBO J. 2000 Feb 15;19(4):631-41.

N-3-氧-己酰高丝氨酸内酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
482.9±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₅NO₄

[ 分子量 ]:
213.230

[ 闪点 ]:
245.9±28.7 °C

[ 精确质量 ]:
213.100113

[ PSA ]:
72.47000

[ LogP ]:
-1.17

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.486

[ 储存条件 ]:
-20°C，密闭，干燥

N-3-氧-己酰高丝氨酸内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

N-3-氧-己酰高丝氨酸内酯文献

Cell adhesion, ammonia removal and granulation of autotrophic nitrifying sludge facilitated by N-acyl-homoserine lactones.

Bioresour. Technol. 196 , 550-8, (2015)

In this study, six N-acyl-homoserine lactone (AHL) molecules (C6-HSL, C8-HSL, C10-HSL, 3-oxo-C6-HSL, 3-oxo-C8-HSL and 3-oxo-C10-HSL) were each dosed into a bioreactor and seeded using autotrophic nitr...

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.

Bioorg. Med. Chem. Lett. 18 , 5978-81, (2008)

A focused library of N-aryl l-homoserine lactones was designed around known lactone leads and evaluated for antagonistic and agonistic activity against quorum-sensing receptors in Agrobacterium tumefa...

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