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KM11060

KM11060用途

KM11060是F508del-CFTR校正剂。

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KM11060名称

[ CAS 号 ]:
774549-97-2

[ 中文名 ]:
7-氯-4-[4-[(4-氯苯基)磺酰基]-1-哌嗪基]喹啉

[ 英文名 ]:
KM 11060

[英文别名 ]:

KM 11060
KM11060

KM11060生物活性

[ 描述 ]:

KM11060是F508del-CFTR校正剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> CFTR

研究领域 >> 内分泌

[参考文献]

[1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.

[2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.

[相关活性小分子]

KM11060物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
607.3±65.0 °C at 760 mmHg

[ 分子式 ]:
C₁₉H₁₇Cl₂N₃O₂S

[ 分子量 ]:
422.328

[ 闪点 ]:
321.1±34.3 °C

[ 精确质量 ]:
421.041840

[ PSA ]:
61.89000

[ LogP ]:
4.19

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.676

[ 储存条件 ]:
2-8℃

KM11060MSDS

KM11060安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2935009090

KM11060合成路线

KM11060上下游产品

KM11060上游产品

KM11060下游产品

KM11060海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

KM11060文献

Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.

PLoS ONE 8 , e82683, (2013)

Mutation of CFTR (cystic fibrosis transmembrane conductance regulator) leads to cystic fibrosis (CF). Patients with CF develop abnormalities of blood platelets and recurrent lung inflammation. However...

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