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羊毛甾醇

羊毛甾醇用途

Lanosterol 是胆固醇生物合成中的关键三萜中间体。

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羊毛甾醇名称

[ CAS 号 ]:
79-63-0

[ 中文名 ]:
羊毛甾醇

[ 英文名 ]:
Lanosterin

[中文别名 ]:

[英文别名 ]:

Lanosterol
Lanster
MFCD00021108
Lanosta-8,24-dien-3-β-ol
Lanosterin
Kriptosterol
DUSOGEL
botalanbase
(3β)-Lanosta-8,24-dien-3-ol
Criptosterol

羊毛甾醇生物活性

[ 描述 ]:

Lanosterol 是胆固醇生物合成中的关键三萜中间体。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 类固醇

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Chen N, et al. Biosynthetic Mechanism of Lanosterol: Cyclization. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8693-6.

[相关活性小分子]

羊毛甾醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
498.9±44.0 °C at 760 mmHg

[ 熔点 ]:
137 °C

[ 分子式 ]:
C₃₀H₅₀O

[ 分子量 ]:
426.717

[ 闪点 ]:
221.1±20.7 °C

[ 精确质量 ]:
426.386169

[ PSA ]:
20.23000

[ LogP ]:
11.00

[ 外观性状 ]:
powder | white

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.530

[ 储存条件 ]:
−20°C

羊毛甾醇MSDS

羊毛甾醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OE3360000

CHEMICAL NAME :: Lanosta-8,24-dien-3-ol, (3-beta)-

CAS REGISTRY NUMBER :: 79-63-0

BEILSTEIN REFERENCE NO. :: 2226449

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H50-O

MOLECULAR WEIGHT :: 426.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 1819 ug/kg

SEX/DURATION :: female 13 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,528,1992

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羊毛甾醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
OE3360000

羊毛甾醇合成路线

羊毛甾醇上下游产品

羊毛甾醇上游产品

羊毛甾醇下游产品

羊毛甾醇制备

1. 从甲醇-丙酮中得晶体，从乙醇中得针晶。

2. 烟草：FC，8；由角鲨烯的环化制备。

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羊毛甾醇文献

The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.

Biochim. Biophys. Acta 1851(2) , 141-51, (2015)

Sterol uptake in the pathogenic fungus, Candida glabrata, occurs via the sterol transporter, CgAus1p. Azole inhibition of sterol biosynthesis can under certain circumstances be reversed by adding exog...

Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.

Food Chem. Toxicol. 53 , 317-24, (2013)

Ganodermanondiol, a biologically active compound, was isolated from the Lingzhi mushroom (Ganoderma lucidum). The present study examined the protective effects of ganodermanondiol against tert-butyl h...

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Nat. Commun. 6 , 8613, (2015)

FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specificall...

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羊毛甾醇

羊毛甾醇用途

羊毛甾醇名称

羊毛甾醇生物活性

羊毛甾醇物理化学性质

羊毛甾醇MSDS

详细MSDS(安全技术说明书)

羊毛甾醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

羊毛甾醇安全信息

羊毛甾醇合成路线

详细合成路线

羊毛甾醇上下游产品

羊毛甾醇上游产品

羊毛甾醇下游产品

羊毛甾醇制备

羊毛甾醇文献

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