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溴甲辛托品

溴甲辛托品用途

甲溴化异丙肾上腺素是一种口服活性抗胆碱能毒蕈碱拮抗剂。甲溴化异丙肾上腺素可抑制胃酸分泌,并用作消化性溃疡的辅助药物[1]。

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溴甲辛托品名称

[ CAS 号 ]:
80-50-2

[ 中文名 ]:
溴甲辛托品

[ 英文名 ]:
Endovalpin

[中文别名 ]:

[英文别名 ]:

octatropine methylbromide
Methoxy(benzene-2,4,6-d3)
Anisole-2,4,6-d3
1,3,5-trideuterio-2-methoxy-benzene
2,4,6-Trideutero-anisol
anisotropine methobromide
2,4,6-Trideuterio-anisol
anisotropine methyl bromide
2,4,6-trideuterioanisole

溴甲辛托品生物活性

[ 描述 ]:

甲溴化异丙肾上腺素是一种口服活性抗胆碱能毒蕈碱拮抗剂。甲溴化异丙肾上腺素可抑制胃酸分泌,并用作消化性溃疡的辅助药物[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 代谢疾病

[体内研究]

甲溴化异丙肾上腺素(静脉注射,0.5μM和0.1ml,一次)可阻断清醒或麻醉狗的乙酰胆碱诱导的发声、肠痉挛和肠收缩[1]。动物模型：体重2.5-5.0kg的狗[1]剂量：0.5μM,0.1ml给药：静脉注射；一次结果：抑制乙酰胆碱诱导的发声,最大抑制率为85.1%,抑制乙酰胆碱酯酶诱导的肠痉挛,最大抑制为79%。

[参考文献]

[1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20.

溴甲辛托品物理化学性质

[ 熔点 ]:
329ºC

[ 分子式 ]:
C₂₇H₄₃NO₉

[ 分子量 ]:
525.63200

[ 精确质量 ]:
525.29400

[ PSA ]:
174.31000

[ 储存条件 ]:
2-8°C

溴甲辛托品毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3710000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, bromide, 2-propylvalerate

CAS REGISTRY NUMBER :: 80-50-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H32-N-O2.Br

MOLECULAR WEIGHT :: 362.41

WISWESSER LINE NOTATION :: T56 A AKTJ A1 A1 GOVY3&3 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 705 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2759 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)

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溴甲辛托品安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332-H400

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36-61-60

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
YM3710000

溴甲辛托品文献

[Pediatric use of a drug, anticholinergic and muscle relaxant on the gastrointestinal tract].

Pediatr. Med. Chir. 4(1-2) , 79-81, (1982)

[Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study].

ZFA (Stuttgart.) 58(27) , 1481-4, (1982)

[Preliminary clinical research on a new anti-ulcer drug].

Clin. Ter. 89(4) , 365-71, (1979)

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