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番泻苷A

番泻苷A用途

Sennoside A 是一种蒽醌苷,在番泻叶 (Cassia angustifolia) 的叶子和豆荚中大量发现。Sennoside A 是一种 HIV-1 抑制剂,抑制 HIV-1 复制。

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番泻苷A名称

[ CAS 号 ]:
81-27-6

[ 中文名 ]:
番泻苷 A

[ 英文名 ]:
Sennoside A

[中文别名 ]:

[英文别名 ]:

Tomato juice
SennosideA
PURSENNID
Sennoside A
Sennoside B
EINECS 201-339-9
MFCD00151527
Glysennid
GLYSENNIDE
SENNOSIDA

番泻苷A生物活性

[ 描述 ]:

Sennoside A 是一种蒽醌苷,在番泻叶 (Cassia angustifolia) 的叶子和豆荚中大量发现。Sennoside A 是一种 HIV-1 抑制剂,抑制 HIV-1 复制。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[参考文献]

[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422.

[2]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391.

番泻苷A物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
1144.8±65.0 °C at 760 mmHg

[ 熔点 ]:
200-240ºC

[ 分子式 ]:
C₄₂H₃₈O₂₀

[ 分子量 ]:
862.739

[ 闪点 ]:
348.6±27.8 °C

[ 精确质量 ]:
862.195618

[ PSA ]:
347.96000

[ LogP ]:
1.88

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
室温

番泻苷A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
22-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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番泻苷A文献

The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.

Biol. Pharm. Bull. 35(12) , 2204-8, (2012)

Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinant...

The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

Biol. Pharm. Bull. 34(9) , 1438-42, (2011)

Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influe...

Effects of optimized-SopungSunkiwon on memory impairment and enhancement.

Neurosci. Lett. 491(2) , 93-8, (2011)

Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investiga...

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