< 生产厂家价格 >

醌茜素

醌茜素用途

喹茜素是一种有效、选择性和细胞渗透性蛋白激酶CK2抑制剂,Ki约为50 nM,IC50为110 nM。喹茜素可诱导某些癌细胞凋亡[1]。

点击显示

醌茜素名称

[ CAS 号 ]:
81-61-8

[ 中文名 ]:
醌茜素

[ 英文名 ]:
Quinalizarin

[中文别名 ]:

[英文别名 ]:

1,2,5,8-tetrahydroxy-9,10-anthracenedione
Alizarinbordeaux
9,10-Anthracenedione, 1,2,5,8-tetrahydroxy-
MFCD00001205
9,10-Anthracenedione,1,2,5,8-tetrahydroxy
Alizarine Bordeaux B
1,2,5,8-Tetrahydroxy-9,10-anthraquinone
Mordant Violet 26
Khinalizarin
Alizarine Bordeaux

醌茜素生物活性

[ 描述 ]:

喹茜素是一种有效、选择性和细胞渗透性蛋白激酶CK2抑制剂,Ki约为50 nM,IC50为110 nM。喹茜素可诱导某些癌细胞凋亡[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 酪蛋白激酶

信号通路 >> 干细胞及 Wnt 通路 >> 酪蛋白激酶

[ 靶点 ]

CK2:~50 nM (Ki)

CK2:110 nM (IC50)

[参考文献]

[1]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15.

醌茜素物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
517.1±45.0 °C at 760 mmHg

[ 熔点 ]:
99 °C

[ 分子式 ]:
C₁₄H₈O₆

[ 分子量 ]:
272.210

[ 闪点 ]:
280.6±25.2 °C

[ 精确质量 ]:
272.032074

[ PSA ]:
115.06000

[ LogP ]:
5.18

[ 外观性状 ]:
红色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.815

[ 储存条件 ]:
room temp

醌茜素MSDS

醌茜素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8069900

CHEMICAL NAME :: Anthraquinone, 1,2,5,8-tetrahydroxy-

CAS REGISTRY NUMBER :: 81-61-8

BEILSTEIN REFERENCE NO. :: 1889617

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H8-O6

MOLECULAR WEIGHT :: 272.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ EQ KQ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

点击显示

醌茜素安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

醌茜素合成路线

醌茜素上下游产品

醌茜素上游产品

醌茜素下游产品

醌茜素文献

Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127.

Biochim. Biophys. Acta 1853 , 1693-701, (2015)

In eukaryotic protein synthesis the translation initiation factor 3 (eIF3) is a key player in the recruitment and assembly of the translation initiation machinery. Mammalian eIF3 consists of 13 subuni...

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Cell. Mol. Life Sci. 71(21) , 4243-58, (2014)

Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific pep...

Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.

Int. J. Oncol. 48 , 1073-84, (2016)

The purpose of this study was to investigate the influence of quinalizarin on the radiosensitivity of nasopharyngeal carcinoma (NPC) cells and the relevant underlying mechanisms. Human NPC cell lines ...

更多文献

醌茜素