乙酰克里定

乙酰克里定用途

乙酰胆碱是M3毒蕈碱乙酰胆碱受体的调节剂。Aceclidine是一种环麻痹剂、表面活性剂、张力调节剂和可选的增粘剂和抗氧化剂。Aceclidine有可能用于研究诸如眼屈光不正、口干症、干燥综合征、青光眼、结膜炎、泪腺疾病和内斜视等疾病(摘自专利US20150290125A1/US20110091459A1)[1][2]。

点击显示

乙酰克里定名称

[ CAS 号 ]:
827-61-2

[ 中文名 ]:
乙酰克里定

[ 英文名 ]:
Aceclidine

[中文别名 ]:

[英文别名 ]:

3-Acetoxyquinuclidine
Quinuclidin-3-yl acetate
aceclidine
Glaucostat

乙酰克里定生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[ 靶点 ]

M3 muscarinic acetylcholine receptor[1]

[参考文献]

[1]. Gerald Horn, et al. Storage Stable Compositions and Methods for the Treatment of Refractive Errors of the Eye. Patent US20150290125A1.

[2]. Thomas G. Gant, et al. Imidazole modulators of muscarinic acetylcholine receptor m3. Patent US20110091459A1.

乙酰克里定物理化学性质

[ 沸点 ]:
221.5ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₅NO₂

[ 分子量 ]:
169.22100

[ 闪点 ]:
85ºC

[ 精确质量 ]:
169.11000

[ PSA ]:
29.54000

[ LogP ]:
0.58160

[ 储存条件 ]:
库房通风低温干燥

乙酰克里定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD6195000

CHEMICAL NAME :: 3-Quinuclidinol, acetate (ester)

CAS REGISTRY NUMBER :: 827-61-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H15-N-O2

MOLECULAR WEIGHT :: 169.25

WISWESSER LINE NOTATION :: T66 A B CNTJ AOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 189,295,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,55,1972

点击显示

乙酰克里定安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933990090

乙酰克里定合成路线

详细合成路线

乙酰克里定上下游产品

乙酰克里定上游产品

乙酰克里定下游产品

乙酰克里定海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%