Cyclosomatostatin

Cyclosomatostatin用途

Cyclosomatostatin 是有效的生长抑素 (SST) 受体拮抗剂。Cyclosomatostatin 在直肠癌 (CRC) 细胞中可以抑制 1 型生长抑素受体 (SSTR1) 信号传导,并降低结细胞增殖,ALDH+ 细胞群体大小和球形成。

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Cyclosomatostatin名称

[ CAS 号 ]:
84211-54-1

[ 中文名 ]:
环抑素

[ 英文名 ]:
Cyclosomatostatin

[英文别名 ]:

Cyclosomatostatin
C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR: BZL]
Cyclo(7-Aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])

Cyclosomatostatin生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体

[参考文献]

[1]. Shirin R Modarai, et al. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. BMC Cancer. 2016 Dec 7;16(1):941.

Cyclosomatostatin物理化学性质

[ 密度 ]:
1.147g/cm3

[ 沸点 ]:
1118.4ºC at 760 mmHg

[ 分子式 ]:
C₄₄H₅₇N₇O₆

[ 分子量 ]:
779.96700

[ 闪点 ]:
630.2ºC

[ 精确质量 ]:
779.43700

[ PSA ]:
196.54000

[ LogP ]:
6.05120

[ 折射率 ]:
1.558

[ 储存条件 ]:
-20°C

CyclosomatostatinMSDS

详细MSDS(安全技术说明书)

Cyclosomatostatin安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Cyclosomatostatin文献

Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

J. Neurosci. 34(35) , 11769-80, (2014)

Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...

Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.

Korean J. Physiol. Pharmacol. 12(5) , 253-8, (2008)

Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nocice...

Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine.

Pharmacol. Res. 95-96 , 71-81, (2015)

Curcumin (CUR) has been proven to be clinically effective in rheumatoid arthritis (RA) therapy, but its low oral bioavailability eclipses existent evidence that attempts to explain the underlying mech...

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