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DL-AP7

DL-AP7用途

DL-AP7是一种竞争性NMDA拮抗剂和抗惊厥剂。DL-AP7阻断NMDA诱导的惊厥,并损害小鼠被动回避任务的学习能力[1]。

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DL-AP7名称

[ CAS 号 ]:
85797-13-3

[ 英文名 ]:
DL-AP7

[英文别名 ]:

2-amino-5-phosphonovaleric acid
acide amino-6 carboxy-6 hexylphosphonique
2-amino-5-phosphopentanoicacid
DL-APV
[3H]-DL-AP7
D-2-amino-5-phosphonovaleric acid
[3H]-DL-AP 5
DL-2-amino-5-phosphonovaleric acid
d-(+/-)-2-amino-5-phosphonopentanoic acid
5-PHOSPHONO-DL-NORVALINE

DL-AP7生物活性

[ 描述 ]:

DL-AP7是一种竞争性NMDA拮抗剂和抗惊厥剂。DL-AP7阻断NMDA诱导的惊厥,并损害小鼠被动回避任务的学习能力[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[体内研究]

DL-AP7(ICV)阻断NMDA诱导的惊厥(ED50=0.22 nmol/小鼠),并损害小鼠被动回避任务中的学习表现[1]。

[参考文献]

[1]. Chiamulera C, et al. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning. Psychopharmacology (Berl). 1990;102(4):551-552.

DL-AP7物理化学性质

[ 密度 ]:
1.39g/cm3

[ 沸点 ]:
480.1ºC at 760mmHg

[ 分子式 ]:
C₇H₁₆NO₅P

[ 分子量 ]:
225.17900

[ 闪点 ]:
244.2ºC

[ 精确质量 ]:
225.07700

[ PSA ]:
130.66000

[ LogP ]:
0.83670

[ 储存条件 ]:
-20°C，密闭，干燥

DL-AP7MSDS

DL-AP7毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ1927500

CHEMICAL NAME :: Heptanoic acid, 2-amino-7-phosphono-

CAS REGISTRY NUMBER :: 85797-13-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H16-N-O5-P

MOLECULAR WEIGHT :: 225.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,575,1985

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DL-AP7安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MJ1927500

[ 海关编码 ]:
2931900090

DL-AP7合成路线

DL-AP7上下游产品

DL-AP7上游产品

DL-AP7下游产品

DL-AP7海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

DL-AP7文献

Differentiation of neurons restricts Arbovirus replication and increases expression of the alpha isoform of IRF-7.

J. Virol. 89(1) , 48-60, (2014)

Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis. To identify factors associated with maturation...

Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat.

PLoS ONE 7(12) , e53111, (2012)

We have previously reported that chemical stimulation of the hypothalamic arcuate nucleus (ARCN) in the rat elicited increases as well as decreases in blood pressure (BP) and sympathetic nerve activit...

L-NOARG-induced catalepsy can be influenced by glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus.

Behav. Brain Res. 234(2) , 149-54, (2012)

The inferior colliculus (IC), a midbrain structure that processes acoustic information of aversive nature, is distinguished from other auditory nuclei in the brainstem by its connections with structur...

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