2-叔丁基-4-羟基茴香醚

2-叔丁基-4-羟基茴香醚用途

3-tert-Butyl-4-methoxyphenol 是 alkyl/ethe 类 PROTAC linker,具有杀虫活性。3-tert-Butyl-4-methoxyphenol 还诱导 A/HeJ 小鼠的肝和前胃组织中谷胱甘肽 (GSH) S-转移酶和环氧化物水解酶的活性增加,调节致癌物代谢系统。

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2-叔丁基-4-羟基茴香醚名称

[ CAS 号 ]:
88-32-4

[ 中文名 ]:
2-叔丁基-4-羟基茴香醚

[ 英文名 ]:
TBMP

[英文别名 ]:

2-TERT-BUTYL-4-HYDROXYANISOLE
4-Methoxy-3-te
2-BHA
3-tert-Bha
2-TERT-BUTYLHYDROXYANISOLE
3-tert-butyl-4-methoxy-pheno
2-T-BUTYL-4-HYDROXYANISOLE
3-TERT-BUTYL-4-METHOXYPHENOL
4-Methoxy-3

2-叔丁基-4-羟基茴香醚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[参考文献]

[1]. Lam LK, et al. Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice. Cancer Res. 1981 Oct;41(10):3940-3.

[2]. Insecticide for vermin of order coleoptera. Japan, JP55136202 A 1980-10-23.

2-叔丁基-4-羟基茴香醚物理化学性质

[ 密度 ]:
1.009 g/cm3

[ 沸点 ]:
293.3ºC at 760 mmHg

[ 熔点 ]:
64℃

[ 分子式 ]:
C₁₁H₁₆O₂

[ 分子量 ]:
180.24

[ 闪点 ]:
136ºC

[ 精确质量 ]:
180.11500

[ PSA ]:
29.46000

[ LogP ]:
2.69830

[ 外观性状 ]:
固体

[ 折射率 ]:
1.507

[ 储存条件 ]:
库房通风低温干燥

2-叔丁基-4-羟基茴香醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK1575010

CHEMICAL NAME :: Phenol, 3-tert-butyl-4-methoxy-

CAS REGISTRY NUMBER :: 88-32-4

BEILSTEIN REFERENCE NO. :: 2209222

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H16-O2

MOLECULAR WEIGHT :: 180.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 27 gm/kg/3W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 76,143,1986

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2-叔丁基-4-羟基茴香醚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

2-叔丁基-4-羟基茴香醚合成路线

详细合成路线

2-叔丁基-4-羟基茴香醚海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2-叔丁基-4-羟基茴香醚文献

Modulation by dietary factors of BHA-induced alterations in cell kinetics of gastro-intestinal tract tissues in rats.

Food Chem. Toxicol. 29(2) , 79-85, (1991)

To determine the effects of dietary ethanol or fibre on 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced alterations in cell kinetics in gastro-intestinal tract tissues, groups of six male Wistar rats w...

Antioxidant properties of melatonin: a pulse radiolysis study.

Free Radic. Biol. Med. 26(5-6) , 557-65, (1999)

Various one-electron oxidants such as OH*, tert-BuO*, CCl3OO*, Br2*- and N3*, generated pulse radiolytically in aqueous solutions at pH 7, were scavenged by melatonin to form two main absorption bands...

Chemoprevention of cancer: phenolic antioxidants (BHT, BHA).

Int. J. Biochem. 20(7) , 639-51, (1988)

1. The synthetic phenolic antioxidants (e.g. BHT, BHA) added to human and animal food are able to lengthen the life of organisms and lower the incidence of cancer caused by chemical compounds. 2. On t...

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