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油酸三乙醇胺

油酸三乙醇胺用途

Tomelukast (LY171883) 是一种具有口服活性的 leukotriene D4 和 E4 拮抗剂。Tomelukast 可用于哮喘的研究。

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油酸三乙醇胺名称

[ CAS 号 ]:
88107-10-2

[ 中文名 ]:
油酸三乙醇胺

[ 英文名 ]:
LY 171883

[英文别名 ]:

MFCD00211057
Tomelukast
Tomelukastum

油酸三乙醇胺生物活性

[ 描述 ]:

Tomelukast (LY171883) 是一种具有口服活性的 leukotriene D4 和 E4 拮抗剂。Tomelukast 可用于哮喘的研究。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 白三烯受体

研究领域 >> 炎症/免疫

[ 靶点 ]

leukotriene D4, leukotriene E4[1]

[参考文献]

[1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67.

油酸三乙醇胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
553.0±60.0 °C at 760 mmHg

[ 熔点 ]:
117-119℃

[ 分子式 ]:
C₁₆H₂₂N₄O₃

[ 分子量 ]:
318.37

[ 闪点 ]:
288.3±32.9 °C

[ 精确质量 ]:
318.169189

[ PSA ]:
100.99000

[ LogP ]:
3.27

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
Store at +4°C

油酸三乙醇胺MSDS

油酸三乙醇胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5780800

CHEMICAL NAME :: Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)p henyl)-

CAS REGISTRY NUMBER :: 88107-10-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O3

MOLECULAR WEIGHT :: 318.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18250 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3010 mg/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 63875 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg/1W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991

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油酸三乙醇胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KM5780800

油酸三乙醇胺合成路线

油酸三乙醇胺上下游产品

油酸三乙醇胺上游产品

油酸三乙醇胺下游产品

油酸三乙醇胺制备

将油酸加入皂化锅内用蒸汽加热至熔融后，缓缓加入三乙醇胺水溶液，在50～60℃下反应4h,冷却，出料即为成品。

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油酸三乙醇胺文献

Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.

Toxicology 300(1-2) , 92-9, (2012)

The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although N...

Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa.

Prostaglandins 51(1) , 69-79, (1996)

To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging f...

Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart.

Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 385-7, (1995)

更多文献

油酸三乙醇胺

油酸三乙醇胺用途

油酸三乙醇胺名称

油酸三乙醇胺生物活性

油酸三乙醇胺物理化学性质

油酸三乙醇胺MSDS

详细MSDS(安全技术说明书)

油酸三乙醇胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

油酸三乙醇胺安全信息

油酸三乙醇胺合成路线

详细合成路线

油酸三乙醇胺上下游产品

油酸三乙醇胺上游产品

油酸三乙醇胺下游产品

油酸三乙醇胺制备

油酸三乙醇胺文献

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