< 生产厂家价格 >

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸用途

GW9508是FFA1(GPR40)激动剂,pEC50为7.32,比对GPR120的抑制性高100倍,可通过葡萄糖敏感的方式刺激胰岛素分泌。

点击显示

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸名称

[ CAS 号 ]:
885101-89-3

[ 中文名 ]:
3-(4-((3-苯氧基苄基)氨基)苯基)丙酸

[ 英文名 ]:
GW9508

[中文别名 ]:

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸

[英文别名 ]:

3-{4-[(3-Phenoxybenzyl)amino]phenyl}propanoic acid
gw9508
GW-9508

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸生物活性

[ 描述 ]:

GW9508是FFA1(GPR40)激动剂,pEC50为7.32,比对GPR120的抑制性高100倍,可通过葡萄糖敏感的方式刺激胰岛素分泌。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR40

研究领域 >> 代谢疾病

[参考文献]

[1]. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.

[2]. Zhao YF, et al. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J Endocrinol, 2008, 198(3), 533-540.

[3]. Fujita T, et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol, 2011, 131(8), 1660-1667.

[相关活性小分子]

TAK875-消旋体 | GW1100 | DC260126 | PBI-4050钠盐 | GPR40激活剂2 | TUG-770 | AMG 837 | FAA1激动剂-1 | GPR40激活剂1 | AM-1638 | GPR40激动剂2

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
538.4±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₂₁NO₃

[ 分子量 ]:
347.407

[ 闪点 ]:
279.4±28.7 °C

[ 精确质量 ]:
347.152130

[ PSA ]:
58.56000

[ LogP ]:
4.74

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
DMSO: >20mg/mL

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸MSDS

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H335-H410

[ 警示性声明 ]:
P261-P273-P280-P305 + P351 + P338-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-37/38-41-50/53

[ 安全声明 (欧洲) ]:
26-39-60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸合成路线

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸上下游产品

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸上游产品

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸下游产品

4-[[(3-苯氧苯基)甲基]氨基]苯乙酸文献

Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells.

J. Pharmacol. Exp. Ther. 352(2) , 380-94, (2015)

Omega-3 fatty acids (n-3 FAs) are proposed to have many beneficial effects on human health. However, the mechanisms underlying their potential cancer preventative effects are unclear. G protein-couple...

Short-chain fatty acid sensing in rat duodenum.

J. Physiol. 593(3) , 585-99, (2015)

Luminal lipid in the duodenum modulates gastroduodenal functions via the release of gut hormones and mediators such as cholecystokinin and 5-HT. The effects of luminal short-chain fatty acids (SCFAs) ...

Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle.

Am. J. Physiol. Lung Cell. Mol. Physiol. 309 , L970-82, (2015)

Obesity is one of the major risk factors for asthma. Previous studies have demonstrated that free fatty acid levels are elevated in the plasma of obese individuals. Medium- and long-chain free fatty a...

更多文献