< 生产厂家价格 >

巴佛洛霉素/B1

巴佛洛霉素/B1用途

Bafilomycin B1 是从链霉菌属中分离得到的大环内酯类抗生素,可抑制革兰氏阳性菌和真菌,同时为大肠杆菌 K+ 依赖性 ATPase 的抑制剂。

点击显示

巴佛洛霉素/B1名称

[ CAS 号 ]:
88899-56-3

[ 中文名 ]:
巴佛洛霉素/B1

[ 英文名 ]:
Bafilomycin B1

[中文别名 ]:

[英文别名 ]:

bafilomycin b1from streptomyces sp.
ino)carbonyl)-2-methoxy-24-methyl
BafilomycinB1fromStreptomycesgriseus
MFCD00214150

巴佛洛霉素/B1生物活性

[ 描述 ]:

Bafilomycin B1 是从链霉菌属中分离得到的大环内酯类抗生素,可抑制革兰氏阳性菌和真菌,同时为大肠杆菌 K+ 依赖性 ATPase 的抑制剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7972-6.

巴佛洛霉素/B1物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
939.4±65.0 °C at 760 mmHg

[ 分子式 ]:
C₄₄H₆₅NO₁₃

[ 分子量 ]:
815.986

[ 闪点 ]:
521.9±34.3 °C

[ 精确质量 ]:
815.445618

[ PSA ]:
207.38000

[ LogP ]:
3.06

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
−20°C

巴佛洛霉素/B1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NG8841000

CHEMICAL NAME :: Hygrolidin, 37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclo penten-1-yl)amino)car bonyl)- 2-methoxy-24-methyl-

CAS REGISTRY NUMBER :: 88899-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C44-H65-N-O13

MOLECULAR WEIGHT :: 816.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981

点击显示

巴佛洛霉素/B1安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
NG8841000

巴佛洛霉素/B1上下游产品

巴佛洛霉素/B1上游产品

巴佛洛霉素/B1下游产品

巴佛洛霉素/B1文献

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988)

Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast,...

Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.

Biochim. Biophys. Acta 1126(1) , 41-8, (1992)

Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 mi...

The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.

Cell Biol. Toxicol. 22(3) , 169-81, (2006)

Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the prot...

更多文献