Lipoxin A4

Lipoxin A4用途

脂蛋白A4(LXA4),一种内源性脂氧合酶衍生的类二十烷酸介质,具有强大的促分解和抗炎双重特性[1]。脂毒素A4抑制与ERK1/2和NF-kB途径相关的人表皮角质形成细胞(NHEK)的增殖和炎性细胞因子/趋化因子的产生[2]。脂毒素A4抑制血清淀粉样蛋白A(SAA)介导的IL-8释放,IC50值为25.74 nM[3]。

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Lipoxin A4名称

[ CAS 号 ]:
89663-86-5

[ 英文名 ]:
Lipoxin A4

[英文别名 ]:

LIPOXIN A
Lipoxin A4
LXA
LXA4

Lipoxin A4生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

[体外研究]

脂蛋白A4(LXA4)抑制NHEK中IL-6和IL-8的表达[2]。脂蛋白A4下调细胞周期蛋白D1的表达[2]。脂毒素A4还抑制NHEK的ERK1/2磷酸化和NF-kB-p65核转位[2]。LXA4(100 nM；预孵育30分钟)在LPS(10μg/mL)刺激或不刺激的情况下抑制NHEK的增殖[2]。LXA4预处理(100 30纳米分钟)下调LPS诱导的角质形成细胞HMGB1的分泌和表达[1]。细胞增殖试验[2]细胞系：正常人表皮角质形成细胞(NHEK)浓度：100 nM培养时间：30分钟结果：LPS(10μg/mL)刺激7天后,NHEK增殖显著增加。然而,当用LXA4预处理30分钟时,NHEK的增殖显著减少。Western Blot分析[1]细胞系：正常人表皮角质形成细胞(NHEK)浓度：100 纳米培养时间：30 分钟结果：LPS可诱导NHEKs胞浆HMGB1蛋白水平升高,LXA4预孵育后HMGB1蛋白水平降低,LPS刺激后细胞核HMGB1蛋白水平降低。

[参考文献]

[1]. Feng Hu, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78(3):181-8.

[2]. Steven Bozinovski, et al. Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):935-40.

[3]. Xinxin Liu, et al. Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis.Sci Rep. 2017 Aug 2;7(1):7100.

Lipoxin A4物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
589.4±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₂O₅

[ 分子量 ]:
352.47

[ 闪点 ]:
324.3±26.6 °C

[ 精确质量 ]:
352.224976

[ PSA ]:
97.99000

[ LogP ]:
2.43

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
-20°C，密闭，干燥

Lipoxin A4安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;

[ 风险声明 (欧洲) ]:
11

[ 安全声明 (欧洲) ]:
7-16

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ 海关编码 ]:
2918199090

Lipoxin A4海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Lipoxin A4文献

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Br. J. Pharmacol. 172(3) , 910-23, (2015)

Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was t...

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