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碘喷托

碘喷托用途

Iopentol是一种非离子型血管内造影剂[1]。

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碘喷托名称

[ CAS 号 ]:
89797-00-2

[ 中文名 ]:
碘喷托

[ 英文名 ]:
Iopentol

[英文别名 ]:

IOPENTOL
UNII-7D6XWX076T
Iopentolum
Imagopaque

碘喷托生物活性

[ 描述 ]:

Iopentol是一种非离子型血管内造影剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Aulie Michelet A. Effects of intravascular contrast media on blood-brain barrier. Comparison between iothalamate, iohexol, iopentol and iodixanol. Acta Radiol. 1987 May-Jun;28(3):329-33.

碘喷托物理化学性质

[ 密度 ]:
2.095g/cm3

[ 沸点 ]:
858.8ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₈I₃N₃O₉

[ 分子量 ]:
835.16

[ 闪点 ]:
473.2ºC

[ 精确质量 ]:
834.89600

[ PSA ]:
195.87000

[ LogP ]:
0.17620

[ 折射率 ]:
1.693

[ 储存条件 ]:
-20°C，密闭，干燥

碘喷托毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ2211000

CHEMICAL NAME :: 1,3-Benzenedicarboxamide, 5-(acetyl(2-hydroxy-3-methoxypropyl)amino)-N,N'-bis (2,3-dihydroxypropyl)-2,4,6-triiodo-

CAS REGISTRY NUMBER :: 89797-00-2

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H28-I3-N3-O9

MOLECULAR WEIGHT :: 835.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22573 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42517 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 553 gm/kg/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thyroid weight

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,45,1987

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碘喷托安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

碘喷托文献

Value of single-dose contrast-enhanced magnetic resonance angiography versus intraarterial digital subtraction angiography in therapy indications in abdominal and iliac arteries.

Cardiovasc. Intervent. Radiol. 30(3) , 376-82, (2007)

The objective of the study was to prove the value of single-dose contrast-enhanced magnetic resonance angiography [three-dimensional (3D) ceMRA] in abdominal and iliac arteries versus the reference st...

[Determination of the distribution volume of contrast media solutions injected intrahepatically: pre-pilot studies for intratumoral gene therapy].

Rofo. 174(3) , 357-62, (2002)

Determination of the intrahepatic distribution volume of two contrast media (CM) by CT-guided application in an ex-vivo and an in-vivo model (pig liver).In pig livers ex-vivo and in-vivo, 131 CT-guide...

Influence of two non-ionic radiographic contrast media with different osmolalities on coagulation in invasive cardiology. A prospective, randomised comparative study.

Acta radiol. 43(6) , 617-22, (2002)

To investigate the influence of two non-ionic radiographic contrast media with different osmolality on thrombocytic function and the plasmatic coagulation system.The study was carried out as a randomi...

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碘喷托