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A-胰凝乳蛋白酶原

A-胰凝乳蛋白酶原用途

胰凝乳蛋白酶原是胰凝乳蛋白酶(HY-108910)的非活性前体。胰凝乳蛋白酶是一种由胰腺产生的丝氨酸蛋白酶[1][2]。

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A-胰凝乳蛋白酶原名称

[ CAS 号 ]:
9035-75-0

[ 中文名 ]:
A-胰凝乳蛋白酶原(限制性化学品禁止进出口)

[ 英文名 ]:
Chymotrypsinogen

[英文别名 ]:

EINECS 232-905-3

A-胰凝乳蛋白酶原生物活性

[ 描述 ]:

胰凝乳蛋白酶原是胰凝乳蛋白酶(HY-108910)的非活性前体。胰凝乳蛋白酶是一种由胰腺产生的丝氨酸蛋白酶[1][2]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶

研究领域 >> 炎症/免疫

[体内研究]

胰凝乳蛋白酶原因其解决炎症症状的能力而被用于组织修复[2]。

[参考文献]

[1]. WALSH, KA, et, al. TRYPSINOGEN AND CHYMOTRYPSINOGEN AS HOMOLOGOUS PROTEINS. Proc Natl Acad Sci U S A. 1964 Oct;52(4):884-9.

[2]. González-Titos A, et, al. Trypsinogen and chymotrypsinogen: potent anti-tumor agents. Expert Opin Biol Ther. 2021 Dec;21(12):1609-1621.

A-胰凝乳蛋白酶原物理化学性质

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
−20°C

A-胰凝乳蛋白酶原安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

A-胰凝乳蛋白酶原文献

Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

J. Pharm. Sci. 104 , 1946-59, (2015)

Adsorption of proteins to solid-fluid interfaces is often empirically found to promote formation of soluble aggregates and larger, subvisible, and visible particles, but key stages in this process are...

Electrodynamic pressure modulation of protein stability in cosolvents.

Biochemistry 52(46) , 8363-73, (2013)

Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein foldin...

Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis.

Am. J. Physiol. Gastrointest. Liver Physiol. 304(5) , G516-26, (2013)

Pancreatic acinar cells express proteinase-activated receptor-2 (PAR2) that is activated by trypsin-like serine proteases and has been shown to exert model-specific effects on the severity of experime...

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