曲吡那敏

曲吡那敏用途

Tripelenamine是一种乙二胺衍生物,是一种有效的组胺H1受体拮抗剂。Tripelenamine可减轻由组胺引起的机体过敏反应。Tripelenamine可用于研究鼻炎、结膜炎、过敏和过敏反应[1][2][3]。
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曲吡那敏名称

[ CAS 号 ]:
91-81-6

[ 中文名 ]:
曲吡那敏

[ 英文名 ]:
Tripelennamine

[英文别名 ]:

曲吡那敏生物活性

曲吡那敏物理化学性质

[ 密度 ]:
1.0683 (rough estimate)

[ 沸点 ]:
185 - 190ºC at 1.7 mm Hg

[ 熔点 ]:
25°C

[ 分子式 ]:
C16H21N3

[ 分子量 ]:
255.35800

[ 精确质量 ]:
255.17400

[ PSA ]:
19.37000

[ LogP ]:
2.64980

[ 外观性状 ]:
油性液体

[ 折射率 ]:
nD25 1.5759-1.5765

曲吡那敏毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US2800000
CHEMICAL NAME :
Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
CAS REGISTRY NUMBER :
91-81-6
BEILSTEIN REFERENCE NO. :
0227074
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C16-H21-N3
MOLECULAR WEIGHT :
255.40
WISWESSER LINE NOTATION :
T6NJ BN1R&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human Liver
DOSE/DURATION :
10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)
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