曲吡那敏
曲吡那敏用途
曲吡那敏名称
[ CAS 号 ]:
91-81-6
[ 中文名 ]:
曲吡那敏
[ 英文名 ]:
Tripelennamine
[英文别名 ]:
- Piribenzil
- Tonaril
- Benzoxale
- Tripelennamin
- Pyribenzamine
- Cizaron
- Resistamine
- tripelenamin
- Tripelennamina
- tripelennamine
曲吡那敏生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
H1 Receptor
[参考文献]
曲吡那敏物理化学性质
[ 密度 ]:
1.0683 (rough estimate)
[ 沸点 ]:
185 - 190ºC at 1.7 mm Hg
[ 熔点 ]:
25°C
[ 分子式 ]:
C16H21N3
[ 分子量 ]:
255.35800
[ 精确质量 ]:
255.17400
[ PSA ]:
19.37000
[ LogP ]:
2.64980
[ 外观性状 ]:
油性液体
[ 折射率 ]:
nD25 1.5759-1.5765
曲吡那敏毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- US2800000
- CHEMICAL NAME :
- Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
- CAS REGISTRY NUMBER :
- 91-81-6
- BEILSTEIN REFERENCE NO. :
- 0227074
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C16-H21-N3
- MOLECULAR WEIGHT :
- 255.40
- WISWESSER LINE NOTATION :
- T6NJ BN1R&2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 61 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Human Liver
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)
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