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胸腺嘧啶

胸腺嘧啶用途

Thymine 是 DNA 的四个碱基之一,可以作为癌症治疗中 5-氟尿嘧啶 (5-FU) 的靶标,其 Km 值为 2.3 μM。

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胸腺嘧啶名称

[ CAS 号 ]:
65-71-4

[ 中文名 ]:
5-甲基脲嘧啶

[ 英文名 ]:
Thymine

[中文别名 ]:

[英文别名 ]:

5-Methyl-2,4(1H,3H)-pyrimidinedione
Clospirazine
5-methylpyrimidine-2,4-dione
5-Methyluracil
THYMINE extrapure
Thymine
4-Hydroxy-5-methylpyrimidin-2(1H)-one
2,4(1H,3H)-Pyrimidinedione, 5-methyl-
5-Methylpyrimidine-2,4-diol
ThyMine 5GR

胸腺嘧啶生物活性

[ 描述 ]:

Thymine 是 DNA 的四个碱基之一,可以作为癌症治疗中 5-氟尿嘧啶 (5-FU) 的靶标,其 Km 值为 2.3 μM。

[ 相关类别 ]:

天然产物 >> 糖和糖苷

研究领域 >> 癌症

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.

[相关活性小分子]

胸腺嘧啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
403.8±37.0 °C at 760 mmHg

[ 熔点 ]:
316 °C

[ 分子式 ]:
C₅H₆N₂O₂

[ 分子量 ]:
126.113

[ 闪点 ]:
198.0±26.5 °C

[ 精确质量 ]:
126.042931

[ PSA ]:
65.72000

[ LogP ]:
-2.09

[ 外观性状 ]:
细灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

胸腺嘧啶MSDS

胸腺嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP2100000

CHEMICAL NAME :: Thymine

CAS REGISTRY NUMBER :: 65-71-4

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H6-N2-O2

MOLECULAR WEIGHT :: 126.13

WISWESSER LINE NOTATION :: T6N CNJ BQ DQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 1 gm/L

REFERENCE :: ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7246 No. of Facilities: 437 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 4219 (estimated) No. of Female Employees: 2161 (estimated)

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胸腺嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XP2100000

[ 海关编码 ]:
2933599090

胸腺嘧啶合成路线

胸腺嘧啶上下游产品

胸腺嘧啶上游产品

胸腺嘧啶下游产品

胸腺嘧啶制备

.将新鲜或冷冻的胸腺除脂肪并绞碎后，加3倍量生理盐水，于组织捣碎机中制成匀浆，高速离心后得提取液（组分1）。提取液在80℃加热15min，以沉淀对热不稳定的杂蛋白。离心去掉沉淀，得上清液（组分2）。上清液冷却至4℃，然后加入5倍体积的-10℃丙酮，过滤收集沉淀，干燥后得丙酮粉（组分3）。将丙酮粉溶于pH=70磷酸盐缓冲溶液中，加硫酸铵至饱和度为025，离心去除沉淀，上清液（组分4）调pH=40，再加硫酸铵至饱和度为050，得盐析物。将盐析物溶于pH=8的磷酸盐缓冲溶液，过滤，然后取相对分子质量在15000以下的超滤液。超滤液再经Sephadex G25柱脱盐后，冷冻干燥，可得胸腺素。

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胸腺嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

胸腺嘧啶文献

Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.

MAbs 7(2) , 403-12, (2015)

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-exp...

In vitro investigations on the effect of dermal fibroblasts on keratinocyte responses to ultraviolet B radiation.

Photochem. Photobiol. 90(6) , 1332-9, (2014)

Exposure to ultraviolet radiation is closely linked to the development of skin cancers in humans. The ultraviolet B (UVB) radiation wavelength (280-320 nm), in particular, causes DNA damage in epiderm...

An amplified electrochemical strategy using DNA-QDs dendrimer superstructure for the detection of thymine DNA glycosylase activity.

Biosens. Bioelectron. 71 , 249-55, (2015)

A triple-signal amplification strategy was proposed for highly sensitive and selective detection of thymine DNA glycosylase (TDG) by coupling a dendrimer-like DNA label with the electrochemical method...

更多文献

胸腺嘧啶

胸腺嘧啶用途

胸腺嘧啶名称

胸腺嘧啶生物活性

胸腺嘧啶物理化学性质

胸腺嘧啶MSDS

详细MSDS(安全技术说明书)

胸腺嘧啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

胸腺嘧啶安全信息

胸腺嘧啶合成路线

详细合成路线

胸腺嘧啶上下游产品

胸腺嘧啶上游产品

胸腺嘧啶下游产品

胸腺嘧啶制备

胸腺嘧啶海关

胸腺嘧啶文献

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